NELFA report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0034244Biological processnegative regulation of transcription elongation by RNA polymerase II
GO_0031401Biological processpositive regulation of protein modification process
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0032021Cellular componentNELF complex
GO_0016604Cellular componentnuclear body
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005634Cellular componentnucleus
GO_0005515Molecular functionprotein binding
GO_0003682Molecular functionchromatin binding
GO_0060090Molecular functionmolecular adaptor activity

IV. Literature review

[source]
Gene nameNELFA
Protein nameNegative elongation factor A (NELF-A) (Wolf-Hirschhorn syndrome candidate 2 protein)
Negative elongation factor complex member A
SynonymsP/OKcl.15
WHSC2
DescriptionFUNCTION: Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex. .; FUNCTION: (Microbial infection) The NELF complex is involved in HIV-1 latency possibly involving recruitment of PCF11 to paused RNA polymerase II. .

AccessionsH7C2C7
A0A0C4DFX9
H0Y3X6
F8W954
ENST00000416258.5
ENST00000333877.8
C9JHL4
ENST00000382882.9 [Q9H3P2-1]
ENST00000443203.5
H7C0W2
ENST00000411649.3
ENST00000421397.5
F8WF98
ENST00000458616.1
C9JEM7
ENST00000455762.5
H7C3C2
ENST00000431323.6
ENST00000542778.5
Q9H3P2
ENST00000453740.5
H7C2M8