Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| oligodendrocyte | 11 studies | 27% ± 11% | |
| endothelial cell | 6 studies | 22% ± 4% | |
| macrophage | 4 studies | 19% ± 2% | |
| epithelial cell | 3 studies | 18% ± 2% | |
| microglial cell | 3 studies | 19% ± 2% |
Insufficient scRNA-seq data for expression of NEK3 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| prostate | 100% | 1162.14 | 245 / 245 | 100% | 11.54 | 501 / 502 |
| intestine | 100% | 1496.10 | 966 / 966 | 99% | 24.82 | 521 / 527 |
| pancreas | 99% | 676.83 | 325 / 328 | 99% | 9.23 | 177 / 178 |
| breast | 100% | 1502.83 | 459 / 459 | 98% | 7.63 | 1101 / 1118 |
| brain | 98% | 949.48 | 2591 / 2642 | 100% | 9.20 | 704 / 705 |
| thymus | 100% | 946.47 | 653 / 653 | 97% | 5.36 | 589 / 605 |
| stomach | 99% | 702.67 | 357 / 359 | 98% | 20.93 | 280 / 286 |
| kidney | 100% | 1155.80 | 89 / 89 | 95% | 7.95 | 860 / 901 |
| bladder | 100% | 1082.38 | 21 / 21 | 95% | 11.61 | 481 / 504 |
| lung | 100% | 1353.47 | 577 / 578 | 95% | 6.40 | 1102 / 1155 |
| uterus | 100% | 1541.74 | 170 / 170 | 95% | 7.26 | 435 / 459 |
| esophagus | 99% | 812.82 | 1434 / 1445 | 94% | 9.12 | 172 / 183 |
| skin | 100% | 895.09 | 1809 / 1809 | 89% | 8.35 | 422 / 472 |
| ovary | 100% | 1204.90 | 180 / 180 | 88% | 4.53 | 377 / 430 |
| adrenal gland | 98% | 483.88 | 254 / 258 | 89% | 4.76 | 204 / 230 |
| liver | 96% | 509.76 | 217 / 226 | 83% | 5.82 | 336 / 406 |
| adipose | 100% | 1431.91 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| spleen | 100% | 1064.18 | 241 / 241 | 0% | 0 | 0 / 0 |
| blood vessel | 100% | 1198.03 | 1333 / 1335 | 0% | 0 | 0 / 0 |
| heart | 99% | 645.48 | 851 / 861 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 93% | 6.91 | 27 / 29 |
| eye | 0% | 0 | 0 / 0 | 91% | 7.84 | 73 / 80 |
| tonsil | 0% | 0 | 0 / 0 | 91% | 4.02 | 41 / 45 |
| muscle | 83% | 374.32 | 664 / 803 | 0% | 0 | 0 / 0 |
| peripheral blood | 34% | 136.31 | 317 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0048812 | Biological process | neuron projection morphogenesis |
| GO_0030010 | Biological process | establishment of cell polarity |
| GO_0090043 | Biological process | regulation of tubulin deacetylation |
| GO_0006468 | Biological process | protein phosphorylation |
| GO_0051301 | Biological process | cell division |
| GO_0000278 | Biological process | mitotic cell cycle |
| GO_0030424 | Cellular component | axon |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0005634 | Cellular component | nucleus |
| GO_0004674 | Molecular function | protein serine/threonine kinase activity |
| GO_0106310 | Molecular function | protein serine kinase activity |
| GO_0005515 | Molecular function | protein binding |
| GO_0046872 | Molecular function | metal ion binding |
| GO_0005524 | Molecular function | ATP binding |
| Gene name | NEK3 |
| Protein name | NIMA (Never in mitosis gene a)-related kinase 3, isoform CRA_a (cDNA FLJ16392 fis, clone TRACH2020048, moderately similar to Mus musculus serine/threonine-protein kinase NEK3 (Nek3) mRNA) NIMA related kinase 3 Serine/threonine-protein kinase Nek3 (EC 2.7.11.1) (HSPK 36) (Never in mitosis A-related kinase 3) (NimA-related protein kinase 3) |
| Synonyms | hCG_29120 |
| Description | FUNCTION: Protein kinase which influences neuronal morphogenesis and polarity through effects on microtubules. Regulates microtubule acetylation in neurons. Contributes to prolactin-mediated phosphorylation of PXN and VAV2. Implicated in prolactin-mediated cytoskeletal reorganization and motility of breast cancer cells through mechanisms involving RAC1 activation and phosphorylation of PXN and VAV2. . |
| Accessions | ENST00000618534.4 [P51956-1] ENST00000551355.5 A0A087X203 A0A087WY58 F8VTT4 ENST00000629912.1 P51956 ENST00000618856.1 ENST00000550841.1 Q6ZN64 F8VV00 ENST00000620675.4 A0A087X030 ENST00000610828.5 [P51956-1] ENST00000617054.1 |
