NEIL3 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of NEIL3 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of NEIL3 at tissue level.

III. Associated gene sets

GO_0006285Biological processbase-excision repair, AP site formation
GO_0006284Biological processbase-excision repair
GO_0036297Biological processinterstrand cross-link repair
GO_0045007Biological processdepurination
GO_0005694Cellular componentchromosome
GO_0005654Cellular componentnucleoplasm
GO_0005634Cellular componentnucleus
GO_0003906Molecular functionDNA-(apurinic or apyrimidinic site) endonuclease activity
GO_0003690Molecular functiondouble-stranded DNA binding
GO_1904931Molecular functionMCM complex binding
GO_0140078Molecular functionclass I DNA-(apurinic or apyrimidinic site) endonuclease activity
GO_0019104Molecular functionDNA N-glycosylase activity
GO_0003684Molecular functiondamaged DNA binding
GO_0003697Molecular functionsingle-stranded DNA binding
GO_0000405Molecular functionbubble DNA binding
GO_0008270Molecular functionzinc ion binding

IV. Literature review

[source]
Gene nameNEIL3
Protein nameEndonuclease 8-like 3 (EC 3.2.2.-) (EC 4.2.99.18) (DNA glycosylase FPG2) (DNA glycosylase/AP lyase Neil3) (Endonuclease VIII-like 3) (Nei-like protein 3)
Nei like DNA glycosylase 3
Synonyms
DescriptionFUNCTION: DNA glycosylase which prefers single-stranded DNA (ssDNA), or partially ssDNA structures such as bubble and fork structures, to double-stranded DNA (dsDNA) . Mediates interstrand cross-link repair in response to replication stress: acts by mediating DNA glycosylase activity, cleaving one of the two N-glycosyl bonds comprising the interstrand cross-link, which avoids the formation of a double-strand break but generates an abasic site that is bypassed by translesion synthesis polymerases (By similarity). In vitro, displays strong glycosylase activity towards the hydantoin lesions spiroiminodihydantoin (Sp) and guanidinohydantoin (Gh) in both ssDNA and dsDNA; also recognizes FapyA, FapyG, 5-OHU, 5-OHC, 5-OHMH, Tg and 8-oxoA lesions in ssDNA . No activity on 8-oxoG detected . Also shows weak DNA-(apurinic or apyrimidinic site) lyase activity . In vivo, appears to be the primary enzyme involved in removing Sp and Gh from ssDNA in neonatal tissues . .

AccessionsENST00000513321.1
ENST00000264596.4
D6RAV1
Q8TAT5