Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| type I pneumocyte | 12 studies | 42% ± 16% | |
| fibroblast | 7 studies | 24% ± 10% | |
| type II pneumocyte | 6 studies | 21% ± 5% | |
| podocyte | 5 studies | 38% ± 18% | |
| retinal bipolar neuron | 4 studies | 30% ± 11% | |
| endothelial cell | 4 studies | 30% ± 15% | |
| pericyte | 4 studies | 20% ± 3% | |
| ON-bipolar cell | 3 studies | 40% ± 7% | |
| rod bipolar cell | 3 studies | 44% ± 5% |
Insufficient scRNA-seq data for expression of NDNF at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| prostate | 100% | 963.04 | 245 / 245 | 84% | 9.67 | 421 / 502 |
| lung | 100% | 3787.31 | 578 / 578 | 81% | 37.67 | 932 / 1155 |
| intestine | 95% | 396.57 | 913 / 966 | 66% | 5.13 | 346 / 527 |
| breast | 97% | 466.20 | 444 / 459 | 47% | 3.57 | 521 / 1118 |
| esophagus | 91% | 422.92 | 1318 / 1445 | 38% | 3.02 | 70 / 183 |
| stomach | 67% | 195.16 | 241 / 359 | 56% | 5.58 | 160 / 286 |
| ovary | 99% | 2533.85 | 179 / 180 | 21% | 1.23 | 92 / 430 |
| bladder | 86% | 1317.81 | 18 / 21 | 35% | 5.25 | 176 / 504 |
| kidney | 93% | 1211.55 | 83 / 89 | 24% | 9.70 | 212 / 901 |
| uterus | 85% | 308.59 | 145 / 170 | 22% | 3.10 | 99 / 459 |
| adipose | 91% | 518.45 | 1096 / 1204 | 0% | 0 | 0 / 0 |
| heart | 88% | 280.26 | 754 / 861 | 0% | 0 | 0 / 0 |
| muscle | 85% | 208.01 | 681 / 803 | 0% | 0 | 0 / 0 |
| brain | 26% | 53.14 | 693 / 2642 | 58% | 5.91 | 409 / 705 |
| thymus | 73% | 184.76 | 474 / 653 | 11% | 1.13 | 65 / 605 |
| pancreas | 2% | 2.46 | 6 / 328 | 76% | 8.68 | 136 / 178 |
| skin | 73% | 208.57 | 1324 / 1809 | 4% | 0.68 | 21 / 472 |
| blood vessel | 67% | 268.86 | 900 / 1335 | 0% | 0 | 0 / 0 |
| adrenal gland | 48% | 110.51 | 123 / 258 | 19% | 2.37 | 44 / 230 |
| eye | 0% | 0 | 0 / 0 | 6% | 0.66 | 5 / 80 |
| tonsil | 0% | 0 | 0 / 0 | 4% | 0.17 | 2 / 45 |
| liver | 1% | 0.87 | 2 / 226 | 3% | 0.72 | 11 / 406 |
| spleen | 0% | 0.56 | 1 / 241 | 0% | 0 | 0 / 0 |
| peripheral blood | 0% | 0.52 | 3 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0001525 | Biological process | angiogenesis |
| GO_0030198 | Biological process | extracellular matrix organization |
| GO_0061042 | Biological process | vascular wound healing |
| GO_2000352 | Biological process | negative regulation of endothelial cell apoptotic process |
| GO_0001764 | Biological process | neuron migration |
| GO_0002931 | Biological process | response to ischemia |
| GO_0043524 | Biological process | negative regulation of neuron apoptotic process |
| GO_0007263 | Biological process | nitric oxide mediated signal transduction |
| GO_0044344 | Biological process | cellular response to fibroblast growth factor stimulus |
| GO_0010976 | Biological process | positive regulation of neuron projection development |
| GO_0021828 | Biological process | gonadotrophin-releasing hormone neuronal migration to the hypothalamus |
| GO_0010811 | Biological process | positive regulation of cell-substrate adhesion |
| GO_0071456 | Biological process | cellular response to hypoxia |
| GO_0005615 | Cellular component | extracellular space |
| GO_0005576 | Cellular component | extracellular region |
| GO_0031012 | Cellular component | extracellular matrix |
| GO_0008201 | Molecular function | heparin binding |
| GO_0005539 | Molecular function | glycosaminoglycan binding |
| Gene name | NDNF |
| Protein name | Neuron derived neurotrophic factor Protein NDNF (Neuron-derived neurotrophic factor) |
| Synonyms | UNQ2748/PRO6487 C4orf31 |
| Description | FUNCTION: Secretory protein that plays a role in various cellular processes . Acts as a chemorepellent acting on gonadotropin-releasing hormone (GnRH) expressing neurons regulating their migration to the hypothalamus . Also promotes neuron migration, growth and survival as well as neurite outgrowth and is involved in the development of the olfactory system . May also act through the regulation of growth factors activity and downstream signaling . Also regulates extracellular matrix assembly and cell adhesiveness (By similarity). Promotes endothelial cell survival, vessel formation and plays an important role in the process of revascularization through NOS3-dependent mechanisms . . |
| Accessions | D6RF18 ENST00000379692.9 ENST00000515757.5 ENST00000511408.1 D6R972 Q8TB73 |
