I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| transit amplifying cell | 3 studies | 24% ± 8% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| transit amplifying cell | 3 studies | 24% ± 8% |
Insufficient scRNA-seq data for expression of NDC80 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| uterus | 98% | 238.21 | 167 / 170 | 98% | 33.89 | 452 / 459 |
| skin | 93% | 736.70 | 1684 / 1809 | 91% | 15.78 | 429 / 472 |
| esophagus | 77% | 218.50 | 1118 / 1445 | 98% | 22.27 | 179 / 183 |
| lung | 85% | 124.27 | 493 / 578 | 88% | 16.34 | 1011 / 1155 |
| stomach | 71% | 145.45 | 256 / 359 | 94% | 14.17 | 270 / 286 |
| intestine | 70% | 185.45 | 673 / 966 | 95% | 15.50 | 502 / 527 |
| bladder | 71% | 63.62 | 15 / 21 | 93% | 21.85 | 471 / 504 |
| prostate | 98% | 299.57 | 240 / 245 | 54% | 3.80 | 270 / 502 |
| breast | 51% | 42.46 | 235 / 459 | 89% | 16.91 | 994 / 1118 |
| ovary | 40% | 48.86 | 72 / 180 | 92% | 14.20 | 396 / 430 |
| pancreas | 13% | 10.39 | 41 / 328 | 88% | 9.60 | 156 / 178 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 39.88 | 29 / 29 |
| spleen | 100% | 505.18 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 37.60 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 7.49 | 1 / 1 |
| kidney | 69% | 76.96 | 61 / 89 | 29% | 2.06 | 261 / 901 |
| peripheral blood | 85% | 800.48 | 786 / 929 | 0% | 0 | 0 / 0 |
| adipose | 82% | 107.45 | 986 / 1204 | 0% | 0 | 0 / 0 |
| liver | 22% | 39.28 | 49 / 226 | 59% | 6.55 | 238 / 406 |
| adrenal gland | 53% | 58.16 | 136 / 258 | 25% | 2.69 | 57 / 230 |
| thymus | 54% | 45.09 | 352 / 653 | 22% | 5.50 | 131 / 605 |
| blood vessel | 74% | 76.09 | 994 / 1335 | 0% | 0 | 0 / 0 |
| brain | 1% | 1.38 | 37 / 2642 | 48% | 7.56 | 335 / 705 |
| heart | 31% | 25.41 | 271 / 861 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 13% | 0.77 | 10 / 80 |
| muscle | 6% | 3.52 | 51 / 803 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0008608 | Biological process | attachment of spindle microtubules to kinetochore |
| GO_0014841 | Biological process | skeletal muscle satellite cell proliferation |
| GO_0000278 | Biological process | mitotic cell cycle |
| GO_0007059 | Biological process | chromosome segregation |
| GO_0000070 | Biological process | mitotic sister chromatid segregation |
| GO_0007052 | Biological process | mitotic spindle organization |
| GO_0051310 | Biological process | metaphase chromosome alignment |
| GO_0051298 | Biological process | centrosome duplication |
| GO_0051315 | Biological process | attachment of mitotic spindle microtubules to kinetochore |
| GO_0007057 | Biological process | spindle assembly involved in female meiosis I |
| GO_0000132 | Biological process | establishment of mitotic spindle orientation |
| GO_0051301 | Biological process | cell division |
| GO_0090267 | Biological process | positive regulation of mitotic cell cycle spindle assembly checkpoint |
| GO_0008315 | Biological process | G2/MI transition of meiotic cell cycle |
| GO_0007094 | Biological process | mitotic spindle assembly checkpoint signaling |
| GO_0051383 | Biological process | kinetochore organization |
| GO_0031647 | Biological process | regulation of protein stability |
| GO_0000775 | Cellular component | chromosome, centromeric region |
| GO_0031262 | Cellular component | Ndc80 complex |
| GO_0016020 | Cellular component | membrane |
| GO_0005813 | Cellular component | centrosome |
| GO_0000776 | Cellular component | kinetochore |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0005829 | Cellular component | cytosol |
| GO_0000940 | Cellular component | outer kinetochore |
| GO_0005634 | Cellular component | nucleus |
| GO_0140483 | Molecular function | kinetochore adaptor activity |
| GO_0042802 | Molecular function | identical protein binding |
| GO_0008017 | Molecular function | microtubule binding |
| GO_0005515 | Molecular function | protein binding |
| GO_0030332 | Molecular function | cyclin binding |
| Gene name | NDC80 |
| Protein name | NDC80 kinetochore complex component Kinetochore protein NDC80 Kinetochore protein NDC80 homolog (Highly expressed in cancer protein) (Kinetochore protein Hec1) (HsHec1) (Kinetochore-associated protein 2) (Retinoblastoma-associated protein HEC) |
| Synonyms | hCG_38410 HEC HEC1 KNTC2 |
| Description | FUNCTION: Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity . Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore . The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules . Plays a role in chromosome congression and is essential for the end-on attachment of the kinetochores to spindle microtubules . . FUNCTION: Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. . FUNCTION: Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. . FUNCTION: Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. . |
| Accessions | O14777 I3L4G3 ENST00000575515.1 A8K031 ENST00000574096.1 V9GYM9 ENST00000576274.2 I3L0P0 ENST00000261597.9 Q05DQ6 |
