NCS1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0010975Biological processregulation of neuron projection development
GO_0070588Biological processcalcium ion transmembrane transport
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0030424Cellular componentaxon
GO_0005794Cellular componentGolgi apparatus
GO_0005886Cellular componentplasma membrane
GO_0014069Cellular componentpostsynaptic density
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0005737Cellular componentcytoplasm
GO_0030425Cellular componentdendrite
GO_0005245Molecular functionvoltage-gated calcium channel activity
GO_0005509Molecular functioncalcium ion binding
GO_0008048Molecular functioncalcium sensitive guanylate cyclase activator activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameNCS1
Protein nameNeuronal calcium sensor 1 (NCS-1) (Frequenin homolog) (Frequenin-like protein) (Frequenin-like ubiquitous protein)
SynonymsFLUP
FREQ
DescriptionFUNCTION: Neuronal calcium sensor, regulator of G protein-coupled receptor phosphorylation in a calcium dependent manner. Directly regulates GRK1 (RHOK), but not GRK2 to GRK5. Can substitute for calmodulin (By similarity). Stimulates PI4KB kinase activity (By similarity). Involved in long-term synaptic plasticity through its interaction with PICK1 (By similarity). May also play a role in neuron differentiation through inhibition of the activity of N-type voltage-gated calcium channel (By similarity). .

AccessionsENST00000630865.1 [P62166-2]
ENST00000372398.6 [P62166-1]
P62166