NCAPH report

I. Expression across cell types

Insufficient scRNA-seq data for expression of NCAPH at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of NCAPH at tissue level.

III. Associated gene sets

GO_1905820Biological processpositive regulation of chromosome separation
GO_0007076Biological processmitotic chromosome condensation
GO_1905821Biological processpositive regulation of chromosome condensation
GO_0051301Biological processcell division
GO_0010032Biological processmeiotic chromosome condensation
GO_0051309Biological processfemale meiosis chromosome separation
GO_0051984Biological processpositive regulation of chromosome segregation
GO_0000796Cellular componentcondensin complex
GO_0000794Cellular componentcondensed nuclear chromosome
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0016020Cellular componentmembrane
GO_0005515Molecular functionprotein binding
GO_0003682Molecular functionchromatin binding

IV. Literature review

[source]
Gene nameNCAPH
Protein nameCondensin complex subunit 2 (Barren homolog protein 1) (Chromosome-associated protein H) (hCAP-H) (Non-SMC condensin I complex subunit H) (XCAP-H homolog)
Alternative protein NCAPH
Condensin complex subunit 2
SynonymsCAPH
BRRN
BRRN1
KIAA0074
DescriptionFUNCTION: Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases . Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size . .

FUNCTION: Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. .

AccessionsL8E8P0
ENST00000240423.9 [Q15003-1]
ENST00000435349.1
C9J470
C9JZP1
E9PHA2
ENST00000456906.5
ENST00000455200.5
ENST00000427946.5 [Q15003-2]
Q15003
H7C415
ENST00000435975.5