NCAPD2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_1905820Biological processpositive regulation of chromosome separation
GO_0007076Biological processmitotic chromosome condensation
GO_1905821Biological processpositive regulation of chromosome condensation
GO_0051301Biological processcell division
GO_0010032Biological processmeiotic chromosome condensation
GO_0051984Biological processpositive regulation of chromosome segregation
GO_0000228Cellular componentnuclear chromosome
GO_0000796Cellular componentcondensin complex
GO_0000779Cellular componentcondensed chromosome, centromeric region
GO_0000794Cellular componentcondensed nuclear chromosome
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0000793Cellular componentcondensed chromosome
GO_0016020Cellular componentmembrane
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0005515Molecular functionprotein binding
GO_0042393Molecular functionhistone binding

IV. Literature review

[source]
Gene nameNCAPD2
Protein nameNCAPD2 protein
Condensin complex subunit 1 (Chromosome condensation-related SMC-associated protein 1) (Chromosome-associated protein D2) (hCAP-D2) (Non-SMC condensin I complex subunit D2) (XCAP-D2 homolog)
Non-SMC condensin I complex subunit D2
SynonymsCAPD2
CNAP1
KIAA0159
DescriptionFUNCTION: Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. May target the condensin complex to DNA via its C-terminal domain . May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Required for decatenation of non-centromeric ultrafine DNA bridges during anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size . .

AccessionsF5GZK7
ENST00000539084.5
A0PJ76
E7EN77
ENST00000382457.8
ENST00000539714.5
Q15021
ENST00000315579.10
F5H431