I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| epithelial cell | 3 studies | 20% ± 4% | |
| GABAergic neuron | 3 studies | 27% ± 7% | |
| glutamatergic neuron | 3 studies | 36% ± 9% | |
| endothelial cell | 3 studies | 21% ± 2% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| epithelial cell | 3 studies | 20% ± 4% | |
| GABAergic neuron | 3 studies | 27% ± 7% | |
| glutamatergic neuron | 3 studies | 36% ± 9% | |
| endothelial cell | 3 studies | 21% ± 2% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| brain | 4 studies | 23% ± 8% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| esophagus | 100% | 4539.22 | 1445 / 1445 | 100% | 41.82 | 183 / 183 |
| liver | 100% | 5418.12 | 226 / 226 | 100% | 55.79 | 406 / 406 |
| lung | 100% | 3458.64 | 578 / 578 | 100% | 49.39 | 1155 / 1155 |
| pancreas | 100% | 2921.48 | 328 / 328 | 100% | 63.30 | 178 / 178 |
| prostate | 100% | 5741.96 | 245 / 245 | 100% | 92.46 | 502 / 502 |
| stomach | 100% | 4567.38 | 359 / 359 | 100% | 54.26 | 286 / 286 |
| thymus | 100% | 4502.39 | 653 / 653 | 100% | 69.03 | 604 / 605 |
| breast | 100% | 3631.98 | 459 / 459 | 100% | 70.48 | 1116 / 1118 |
| uterus | 100% | 4263.16 | 170 / 170 | 100% | 57.53 | 458 / 459 |
| kidney | 100% | 4616.21 | 89 / 89 | 100% | 52.75 | 899 / 901 |
| brain | 100% | 4753.14 | 2640 / 2642 | 100% | 102.69 | 703 / 705 |
| intestine | 100% | 5016.24 | 966 / 966 | 100% | 64.33 | 525 / 527 |
| bladder | 100% | 4049.86 | 21 / 21 | 100% | 61.28 | 502 / 504 |
| skin | 100% | 3725.11 | 1809 / 1809 | 100% | 55.90 | 470 / 472 |
| ovary | 100% | 8332.19 | 180 / 180 | 98% | 30.17 | 423 / 430 |
| adrenal gland | 100% | 6829.53 | 258 / 258 | 98% | 69.02 | 226 / 230 |
| adipose | 100% | 3084.35 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 39.03 | 29 / 29 |
| spleen | 100% | 4554.32 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 42.91 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 30.17 | 1 / 1 |
| blood vessel | 100% | 3827.85 | 1334 / 1335 | 0% | 0 | 0 / 0 |
| muscle | 100% | 2774.23 | 802 / 803 | 0% | 0 | 0 / 0 |
| heart | 99% | 2581.03 | 853 / 861 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 99% | 52.41 | 79 / 80 |
| peripheral blood | 66% | 1301.38 | 613 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0110051 | Biological process | metabolite repair |
| GO_0034356 | Biological process | NAD biosynthesis via nicotinamide riboside salvage pathway |
| GO_0008150 | Biological process | biological_process |
| GO_0005575 | Cellular component | cellular_component |
| GO_0005759 | Cellular component | mitochondrial matrix |
| GO_0005515 | Molecular function | protein binding |
| GO_0005524 | Molecular function | ATP binding |
| GO_0047453 | Molecular function | ATP-dependent NAD(P)H-hydrate dehydratase activity |
| Gene name | NAXD |
| Protein name | ATP-dependent (S)-NAD(P)H-hydrate dehydratase (EC 4.2.1.93) (ATP-dependent NAD(P)HX dehydratase) (Carbohydrate kinase domain-containing protein) (NAD(P)HX dehydratase) ATP-dependent (S)-NAD(P)H-hydrate dehydratase (EC 4.2.1.93) (ATP-dependent NAD(P)HX dehydratase) (Carbohydrate kinase domain-containing protein) ATP-dependent NAD(P)H-hydrate dehydratase (EC 4.2.1.93) (NAD(P)HX dehydratase) |
| Synonyms | hCG_32552 CARKD FLJ10769 |
| Description | FUNCTION: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. . FUNCTION: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. . FUNCTION: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. . FUNCTION: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. . FUNCTION: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. . |
| Accessions | A0A7P0TAU0 B4DKX7 A0A7P0T9R3 A0A7P0T9D8 ENST00000680254.1 A0A7P0T906 ENST00000424185.7 [Q8IW45-4] ENST00000680505.1 [Q8IW45-1] ENST00000679389.1 ENST00000679968.1 Q8IW45 ENST00000309957.3 [Q8IW45-2] ENST00000680312.1 |
