NAT8 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0010628Biological processpositive regulation of gene expression
GO_1990000Biological processamyloid fibril formation
GO_0018003Biological processpeptidyl-lysine N6-acetylation
GO_0006749Biological processglutathione metabolic process
GO_0033116Cellular componentendoplasmic reticulum-Golgi intermediate compartment membrane
GO_0005793Cellular componentendoplasmic reticulum-Golgi intermediate compartment
GO_0016020Cellular componentmembrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0008080Molecular functionN-acetyltransferase activity
GO_0047198Molecular functioncysteine-S-conjugate N-acetyltransferase activity
GO_0005515Molecular functionprotein binding
GO_0004468Molecular functionlysine N-acetyltransferase activity, acting on acetyl phosphate as donor

IV. Literature review

[source]
Gene nameNAT8
Protein nameN-acetyltransferase 8 (EC 2.3.1.-) (Acetyltransferase 2) (ATase2) (Camello-like protein 1) (Cysteinyl-conjugate N-acetyltransferase) (CCNAT) (EC 2.3.1.80)
SynonymsCML1
GLA
TSC501
DescriptionFUNCTION: Acetylates the free alpha-amino group of cysteine S-conjugates to form mercapturic acids . This is the final step in a major route for detoxification of a wide variety of reactive electrophiles which starts with their incorporation into glutathione S-conjugates. The glutathione S-conjugates are then further processed into cysteine S-conjugates and finally mercapturic acids which are water soluble and can be readily excreted in urine or bile. Alternatively, may have a lysine N-acetyltransferase activity catalyzing peptidyl-lysine N6-acetylation of various proteins. Thereby, may regulate apoptosis through the acetylation and the regulation of the expression of PROM1 . May also regulate amyloid beta-peptide secretion through acetylation of BACE1 and the regulation of its expression in neurons . .

AccessionsENST00000707634.1
Q9UHE5
ENST00000272425.4