NAPEPLD | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
oligodendrocyte	11 studies	36% ± 18%	Explore
oligodendrocyte precursor cell	7 studies	38% ± 19%	Explore
glutamatergic neuron	6 studies	40% ± 20%	Explore
astrocyte	6 studies	27% ± 11%	Explore
epithelial cell	5 studies	26% ± 4%	Explore
retinal bipolar neuron	4 studies	22% ± 4%	Explore
interneuron	4 studies	36% ± 17%	Explore
endothelial cell	3 studies	25% ± 4%	Explore
retinal cone cell	3 studies	21% ± 5%	Explore
rod bipolar cell	3 studies	23% ± 6%	Explore
transit amplifying cell	3 studies	24% ± 8%	Explore
goblet cell	3 studies	18% ± 2%	Explore
GABAergic neuron	3 studies	39% ± 14%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	10 studies	32% ± 18%	Explore
intestine	3 studies	17% ± 1%	Explore
liver	3 studies	23% ± 5%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
ovary	100%	2269.32	180 / 180	100%	12.66	430 / 430
brain	100%	2545.10	2641 / 2642	100%	18.28	705 / 705
prostate	100%	1346.39	245 / 245	99%	13.12	498 / 502
thymus	100%	2065.76	653 / 653	99%	14.35	596 / 605
breast	100%	894.44	459 / 459	98%	11.01	1100 / 1118
intestine	100%	1780.55	966 / 966	98%	12.28	517 / 527
stomach	100%	1343.40	358 / 359	98%	12.76	279 / 286
pancreas	98%	724.69	323 / 328	98%	11.44	175 / 178
kidney	100%	2020.66	89 / 89	97%	14.35	871 / 901
lung	98%	954.65	569 / 578	98%	9.53	1133 / 1155
bladder	100%	1171.76	21 / 21	96%	8.72	485 / 504
esophagus	97%	864.94	1398 / 1445	99%	12.87	182 / 183
uterus	100%	1244.75	170 / 170	95%	8.08	435 / 459
skin	100%	1021.05	1800 / 1809	92%	13.05	435 / 472
adrenal gland	100%	1347.05	258 / 258	91%	8.19	209 / 230
liver	98%	1006.61	222 / 226	79%	5.30	322 / 406
spleen	100%	2242.39	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	3.10	1 / 1
blood vessel	100%	1421.40	1333 / 1335	0%	0	0 / 0
adipose	99%	907.91	1195 / 1204	0%	0	0 / 0
muscle	95%	601.36	761 / 803	0%	0	0 / 0
tonsil	0%	0	0 / 0	93%	7.27	42 / 45
heart	90%	616.94	778 / 861	0%	0	0 / 0
lymph node	0%	0	0 / 0	86%	5.95	25 / 29
eye	0%	0	0 / 0	57%	3.30	46 / 80
peripheral blood	31%	241.10	284 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0048874	Biological process	host-mediated regulation of intestinal microbiota composition
GO_0001523	Biological process	retinoid metabolic process
GO_0070291	Biological process	N-acylethanolamine metabolic process
GO_0090336	Biological process	positive regulation of brown fat cell differentiation
GO_0001659	Biological process	temperature homeostasis
GO_0050729	Biological process	positive regulation of inflammatory response
GO_0070292	Biological process	N-acylphosphatidylethanolamine metabolic process
GO_0009395	Biological process	phospholipid catabolic process
GO_0043227	Cellular component	membrane-bounded organelle
GO_0005769	Cellular component	early endosome
GO_0031901	Cellular component	early endosome membrane
GO_0070062	Cellular component	extracellular exosome
GO_0005654	Cellular component	nucleoplasm
GO_0005794	Cellular component	Golgi apparatus
GO_0005635	Cellular component	nuclear envelope
GO_0000139	Cellular component	Golgi membrane
GO_0042622	Cellular component	photoreceptor outer segment membrane
GO_0005737	Cellular component	cytoplasm
GO_0070290	Molecular function	N-acylphosphatidylethanolamine-specific phospholipase D activity
GO_0042802	Molecular function	identical protein binding
GO_0032052	Molecular function	bile acid binding
GO_0008270	Molecular function	zinc ion binding

IV. Literature review

[source]

Gene name	NAPEPLD
Protein name	NAPEPLD protein N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D (N-acyl phosphatidylethanolamine phospholipase D) (NAPE-PLD) (NAPE-hydrolyzing phospholipase D) (EC 3.1.4.54) N-acyl phosphatidylethanolamine phospholipase D (N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D)
Synonyms	C7orf18
Description	FUNCTION: D-type phospholipase that hydrolyzes N-acyl-phosphatidylethanolamines (NAPEs) to produce bioactive N-acylethanolamines/fatty acid ethanolamides (NAEs/FAEs) and phosphatidic acid . Cleaves the terminal phosphodiester bond of diacyl- and alkenylacyl-NAPEs, primarily playing a role in the generation of long-chain saturated and monounsaturated NAEs in the brain (By similarity). May control NAPE homeostasis in dopaminergic neuron membranes and regulate neuron survival, partly through RAC1 activation (By similarity). As a regulator of lipid metabolism in the adipose tissue, mediates the crosstalk between adipocytes, gut microbiota and immune cells to control body temperature and weight. In particular, regulates energy homeostasis by promoting cold-induced brown or beige adipocyte differentiation program to generate heat from fatty acids and glucose. Has limited D-type phospholipase activity toward N-acyl lyso-NAPEs (By similarity). .
Accessions	ENST00000611100.2 ENST00000427257.5 ENST00000418294.1 ENST00000633498.1 ENST00000633771.1 ENST00000633783.1 ENST00000420631.5 ENST00000341533.8 ENST00000632159.1 H0Y4Y2 Q4G0T7 ENST00000465647.6 ENST00000622712.4 ENST00000422589.5 Q6IQ20 ENST00000632703.1 C9JGB1 ENST00000417955.5

NAPEPLD report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review