NANOS2 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of NANOS2 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of NANOS2 at tissue level.

III. Associated gene sets

GO_0045835Biological processnegative regulation of meiotic nuclear division
GO_0061157Biological processmRNA destabilization
GO_0007283Biological processspermatogenesis
GO_0006402Biological processmRNA catabolic process
GO_0048477Biological processoogenesis
GO_0030718Biological processgerm-line stem cell population maintenance
GO_0017148Biological processnegative regulation of translation
GO_0000932Cellular componentP-body
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0008047Molecular functionenzyme activator activity
GO_0005515Molecular functionprotein binding
GO_0003729Molecular functionmRNA binding
GO_0008270Molecular functionzinc ion binding

IV. Literature review

[source]
Gene nameNANOS2
Protein nameNanos homolog 2 (NOS-2)
SynonymsNOS2
DescriptionFUNCTION: Plays a key role in the sexual differentiation of germ cells by promoting the male fate but suppressing the female fate. Represses the female fate pathways by suppressing meiosis, which in turn results in the promotion of the male fate. Maintains the suppression of meiosis by preventing STRA8 expression, which is required for premeiotic DNA replication, after CYP26B1 is decreased. Regulates the localization of the CCR4-NOT deadenylation complex to P-bodies and plays a role in recruiting the complex to trigger the degradation of mRNAs involved in meiosis. Required for the maintenance of the spermatogonial stem cell population. Not essential for the assembly of P-bodies but is required for the maintenance of their normal state (By similarity). .

AccessionsP60321
ENST00000341294.4