NAA60 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of NAA60 at tissue level.

III. Associated gene sets

GO_0008283Biological processcell population proliferation
GO_0007059Biological processchromosome segregation
GO_0006474Biological processN-terminal protein amino acid acetylation
GO_0017196Biological processN-terminal peptidyl-methionine acetylation
GO_0006334Biological processnucleosome assembly
GO_0000139Cellular componentGolgi membrane
GO_0042803Molecular functionprotein homodimerization activity
GO_0010485Molecular functionhistone H4 acetyltransferase activity
GO_0004402Molecular functionhistone acetyltransferase activity
GO_0004596Molecular functionpeptide alpha-N-acetyltransferase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameNAA60
Protein namehistone acetyltransferase (EC 2.3.1.48)
N-alpha-acetyltransferase 60, NatF catalytic subunit
N-alpha-acetyltransferase 60 (hNaa60) (EC 2.3.1.259) (Histone acetyltransferase type B protein 4) (HAT4) (EC 2.3.1.48) (N-acetyltransferase 15) (N-alpha-acetyltransferase F) (NatF)
N-alpha-acetyltransferase 60 (EC 2.3.1.259) (EC 2.3.1.48) (Histone acetyltransferase type B protein 4) (N-acetyltransferase 15) (N-alpha-acetyltransferase F)
SynonymsHAT4
NAT15
UNQ2771/PRO7155
DescriptionFUNCTION: N-alpha-acetyltransferase that specifically mediates the acetylation of N-terminal residues of the transmembrane proteins, with a strong preference for N-termini facing the cytosol . Displays N-terminal acetyltransferase activity towards a range of N-terminal sequences including those starting with Met-Lys, Met-Val, Met-Ala and Met-Met . Required for normal chromosomal segregation during anaphase . May also show histone acetyltransferase activity; such results are however unclear in vivo and would require additional experimental evidences . .

AccessionsI3L1B9
ENST00000360862.9 [Q9H7X0-3]
ENST00000649360.1 [Q9H7X0-1]
I3L2K7
ENST00000570372.5
I3L4Q3
ENST00000572942.5 [Q9H7X0-4]
ENST00000572739.5
ENST00000573580.5 [Q9H7X0-3]
ENST00000421765.7 [Q9H7X0-5]
ENST00000573345.5
I3L205
ENST00000575076.5 [Q9H7X0-1]
ENST00000577013.6 [Q9H7X0-3]
ENST00000572169.6 [Q9H7X0-1]
ENST00000576787.5
ENST00000575733.5
ENST00000574950.5
Q9H7X0
I3L2B4
I3L2M6
I3L4Q5
I3L153
ENST00000572584.2 [Q9H7X0-1]
ENST00000572131.5
ENST00000573593.5
I3L1X5
I3L4T5
ENST00000424546.6 [Q9H7X0-2]
ENST00000570819.5 [Q9H7X0-4]
ENST00000407558.9 [Q9H7X0-1]
ENST00000649205.1 [Q9H7X0-1]
ENST00000414063.6 [Q9H7X0-1]
ENST00000576916.5
I3L1T4
ENST00000574328.5
ENST00000572757.5