N6AMT1 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of N6AMT1 at tissue level.

III. Associated gene sets

GO_0045814Biological processnegative regulation of gene expression, epigenetic
GO_0032259Biological processmethylation
GO_0030307Biological processpositive regulation of cell growth
GO_0018364Biological processpeptidyl-glutamine methylation
GO_0009404Biological processtoxin metabolic process
GO_0018872Biological processarsonoacetate metabolic process
GO_0045815Biological processtranscription initiation-coupled chromatin remodeling
GO_0032991Cellular componentprotein-containing complex
GO_0005829Cellular componentcytosol
GO_0035657Cellular componenteRF1 methyltransferase complex
GO_0005634Cellular componentnucleus
GO_0003676Molecular functionnucleic acid binding
GO_1904047Molecular functionS-adenosyl-L-methionine binding
GO_0009007Molecular functionsite-specific DNA-methyltransferase (adenine-specific) activity
GO_0140984Molecular functionhistone H4K12 methyltransferase activity
GO_0036009Molecular functionprotein-glutamine N-methyltransferase activity
GO_0008276Molecular functionprotein methyltransferase activity
GO_0030791Molecular functionarsenite methyltransferase activity
GO_0005515Molecular functionprotein binding
GO_0008757Molecular functionS-adenosylmethionine-dependent methyltransferase activity

IV. Literature review

[source]
Gene nameN6AMT1
Protein nameMethyltransferase N6AMT1 (HemK methyltransferase family member 2) (M.HsaHemK2P) (Lysine N-methyltransferase 9) (EC 2.1.1.-) (Methylarsonite methyltransferase N6AMT1) (EC 2.1.1.-) (Protein N(5)-glutamine methyltransferase) (EC 2.1.1.-)
SynonymsPRED28
KMT9
HEMK2
C21orf127
DescriptionFUNCTION: Methyltransferase that can methylate proteins and, to a lower extent, arsenic . Catalytic subunit of a heterodimer with TRMT112, which monomethylates 'Lys-12' of histone H4 (H4K12me1), a modification present at the promoters of numerous genes encoding cell cycle regulators . Catalytic subunit of a heterodimer with TRMT112, which catalyzes N5-methylation of Glu residue of proteins with a Gly-Gln-Xaa-Xaa-Xaa-Arg motif . Methylates ETF1 on 'Gln-185'; ETF1 needs to be complexed to ERF3 in its GTP-bound form to be efficiently methylated . May also play a role in the modulation of arsenic-induced toxicity by mediating the conversion of monomethylarsonous acid (3+) into the less toxic dimethylarsonic acid . It however only plays a limited role in arsenic metabolism compared with AS3MT . .

AccessionsENST00000303775.10 [Q9Y5N5-1]
Q9Y5N5
ENST00000351429.7 [Q9Y5N5-2]
ENST00000460212.1 [Q9Y5N5-1]