MYRF report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0014003Biological processoligodendrocyte development
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0016540Biological processprotein autoprocessing
GO_0035902Biological processresponse to immobilization stress
GO_0032286Biological processcentral nervous system myelin maintenance
GO_0022010Biological processcentral nervous system myelination
GO_0042220Biological processresponse to cocaine
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0048714Biological processpositive regulation of oligodendrocyte differentiation
GO_0048709Biological processoligodendrocyte differentiation
GO_0031643Biological processpositive regulation of myelination
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0005654Cellular componentnucleoplasm
GO_0005794Cellular componentGolgi apparatus
GO_0005829Cellular componentcytosol
GO_0005634Cellular componentnucleus
GO_0008233Molecular functionpeptidase activity
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0043565Molecular functionsequence-specific DNA binding
GO_0003700Molecular functionDNA-binding transcription factor activity

IV. Literature review

[source]
Gene nameMYRF
Protein nameMyelin regulatory factor (EC 3.4.-.-) (Myelin gene regulatory factor) [Cleaved into: Myelin regulatory factor, N-terminal; Myelin regulatory factor, C-terminal]
Myelin regulatory factor
SynonymsC11orf9
KIAA0954
MRF
DescriptionFUNCTION: [Myelin regulatory factor]: Constitutes a precursor of the transcription factor. Mediates the autocatalytic cleavage that releases the Myelin regulatory factor, N-terminal component that specifically activates transcription of central nervous system (CNS) myelin genes . .; FUNCTION: [Myelin regulatory factor, C-terminal]: Membrane-bound part that has no transcription factor activity and remains attached to the endoplasmic reticulum membrane following cleavage. .; FUNCTION: [Myelin regulatory factor, N-terminal]: Transcription factor that specifically activates expression of myelin genes such as MBP, MOG, MAG, DUSP15 and PLP1 during oligodendrocyte (OL) maturation, thereby playing a central role in oligodendrocyte maturation and CNS myelination. Specifically recognizes and binds DNA sequence 5'-CTGGYAC-3' in the regulatory regions of myelin-specific genes and directly activates their expression. Not only required during oligodendrocyte differentiation but is also required on an ongoing basis for the maintenance of expression of myelin genes and for the maintenance of a mature, viable oligodendrocyte phenotype . .

AccessionsENST00000675345.1
A0A6Q8PFY9
A0A6Q8PFL7
ENST00000278836.10 [Q9Y2G1-1]
ENST00000675319.1
Q9Y2G1
ENST00000675792.1
A0A6Q8PHM1
ENST00000265460.9 [Q9Y2G1-2]