MYLK | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
pericyte	32 studies	49% ± 20%	Explore
smooth muscle cell	32 studies	64% ± 22%	Explore
fibroblast	26 studies	41% ± 12%	Explore
myofibroblast cell	15 studies	63% ± 21%	Explore
astrocyte	14 studies	30% ± 15%	Explore
endothelial cell	11 studies	26% ± 8%	Explore
platelet	10 studies	31% ± 13%	Explore
capillary endothelial cell	10 studies	20% ± 3%	Explore
connective tissue cell	9 studies	36% ± 12%	Explore
oligodendrocyte	7 studies	28% ± 12%	Explore
retinal cone cell	7 studies	37% ± 7%	Explore
megakaryocyte	6 studies	60% ± 22%	Explore
endothelial cell of vascular tree	5 studies	37% ± 18%	Explore
ciliated cell	4 studies	27% ± 10%	Explore
hepatocyte	4 studies	46% ± 16%	Explore
glutamatergic neuron	4 studies	31% ± 9%	Explore
myoepithelial cell	4 studies	72% ± 13%	Explore
glomerular endothelial cell	3 studies	36% ± 1%	Explore
muscle cell	3 studies	74% ± 20%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
intestine	4 studies	24% ± 5%	Explore
uterus	4 studies	26% ± 8%	Explore
brain	4 studies	29% ± 7%	Explore
lung	3 studies	37% ± 13%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
prostate	91%	57438.20	224 / 245	97%	76.07	488 / 502
lung	97%	22051.35	560 / 578	89%	22.08	1031 / 1155
esophagus	79%	96243.49	1139 / 1445	86%	25.40	158 / 183
breast	75%	16790.30	345 / 459	89%	18.42	994 / 1118
bladder	95%	67351.19	20 / 21	66%	13.45	333 / 504
intestine	83%	100330.32	802 / 966	78%	15.01	409 / 527
ovary	73%	16824.40	131 / 180	82%	11.68	352 / 430
uterus	99%	93480.54	168 / 170	54%	41.61	248 / 459
stomach	50%	36735.62	178 / 359	83%	34.18	238 / 286
kidney	27%	4144.70	24 / 89	82%	23.19	743 / 901
blood vessel	99%	70764.90	1326 / 1335	0%	0	0 / 0
pancreas	0%	0	0 / 328	87%	21.07	155 / 178
brain	12%	1946.43	306 / 2642	71%	7.73	501 / 705
skin	21%	2863.17	387 / 1809	58%	7.23	276 / 472
liver	10%	1136.17	23 / 226	68%	7.85	278 / 406
thymus	18%	2418.58	115 / 653	51%	3.80	311 / 605
adipose	67%	14579.11	811 / 1204	0%	0	0 / 0
spleen	62%	10575.32	150 / 241	0%	0	0 / 0
adrenal gland	6%	737.62	15 / 258	44%	4.67	101 / 230
tonsil	0%	0	0 / 0	47%	4.35	21 / 45
lymph node	0%	0	0 / 0	31%	2.29	9 / 29
heart	7%	1135.89	63 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	5%	0.25	4 / 80
muscle	1%	94.99	6 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
peripheral blood	0%	0	0 / 929	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0006939	Biological process	smooth muscle contraction
GO_0032060	Biological process	bleb assembly
GO_0071476	Biological process	cellular hypotonic response
GO_0014820	Biological process	tonic smooth muscle contraction
GO_0030335	Biological process	positive regulation of cell migration
GO_0051928	Biological process	positive regulation of calcium ion transport
GO_0060414	Biological process	aorta smooth muscle tissue morphogenesis
GO_0006468	Biological process	protein phosphorylation
GO_0090303	Biological process	positive regulation of wound healing
GO_0005886	Cellular component	plasma membrane
GO_0001725	Cellular component	stress fiber
GO_0015629	Cellular component	actin cytoskeleton
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_0032154	Cellular component	cleavage furrow
GO_0030027	Cellular component	lamellipodium
GO_0046872	Molecular function	metal ion binding
GO_0005524	Molecular function	ATP binding
GO_0004687	Molecular function	myosin light chain kinase activity
GO_0005516	Molecular function	calmodulin binding
GO_0005515	Molecular function	protein binding
GO_0003779	Molecular function	actin binding

IV. Literature review

[source]

Gene name	MYLK
Protein name	Long myosin light chain kinase MYLK protein Myosin light chain kinase, smooth muscle (MLCK) (smMLCK) (EC 2.7.11.18) (Kinase-related protein) (KRP) (Telokin) [Cleaved into: Myosin light chain kinase, smooth muscle, deglutamylated form] Myosin light chain kinase Myosin light chain kinase, smooth muscle (EC 2.7.11.18) (Telokin) Myosin light chain kinase, smooth muscle
Synonyms	MLCK MLCK1 MYLK1
Description	FUNCTION: Calcium/calmodulin-dependent myosin light chain kinase implicated in smooth muscle contraction via phosphorylation of myosin light chains (MLC). Also regulates actin-myosin interaction through a non-kinase activity. Phosphorylates PTK2B/PYK2 and myosin light-chains. Involved in the inflammatory response (e.g. apoptosis, vascular permeability, leukocyte diapedesis), cell motility and morphology, airway hyperreactivity and other activities relevant to asthma. Required for tonic airway smooth muscle contraction that is necessary for physiological and asthmatic airway resistance. Necessary for gastrointestinal motility. Implicated in the regulation of endothelial as well as vascular permeability, probably via the regulation of cytoskeletal rearrangements. In the nervous system it has been shown to control the growth initiation of astrocytic processes in culture and to participate in transmitter release at synapses formed between cultured sympathetic ganglion cells. Critical participant in signaling sequences that result in fibroblast apoptosis. Plays a role in the regulation of epithelial cell survival. Required for epithelial wound healing, especially during actomyosin ring contraction during purse-string wound closure. Mediates RhoA-dependent membrane blebbing. Triggers TRPC5 channel activity in a calcium-dependent signaling, by inducing its subcellular localization at the plasma membrane. Promotes cell migration (including tumor cells) and tumor metastasis. PTK2B/PYK2 activation by phosphorylation mediates ITGB2 activation and is thus essential to trigger neutrophil transmigration during acute lung injury (ALI). May regulate optic nerve head astrocyte migration. Probably involved in mitotic cytoskeletal regulation. Regulates tight junction probably by modulating ZO-1 exchange in the perijunctional actomyosin ring. Mediates burn-induced microvascular barrier injury; triggers endothelial contraction in the development of microvascular hyperpermeability by phosphorylating MLC. Essential for intestinal barrier dysfunction. Mediates Giardia spp.-mediated reduced epithelial barrier function during giardiasis intestinal infection via reorganization of cytoskeletal F-actin and tight junctional ZO-1. Necessary for hypotonicity-induced Ca(2+) entry and subsequent activation of volume-sensitive organic osmolyte/anion channels (VSOAC) in cervical cancer cells. Responsible for high proliferative ability of breast cancer cells through anti-apoptosis. .
Accessions	ENST00000360304.8 [Q15746-1] A0A8I5QJW9 ENST00000685021.1 [Q15746-7] ENST00000504946.6 ENST00000691933.1 A0A8J9G5A3 ENST00000686039.1 ENST00000686761.1 [Q15746-1] ENST00000687375.1 [Q15746-10] ENST00000686245.1 A0A8I5QKW8 Q05D81 ENST00000688223.1 A0A8I5KTQ1 ENST00000686406.1 [Q15746-6] ENST00000692356.1 ENST00000464489.5 A0A8I5KQY6 ENST00000684882.1 ENST00000578202.2 A0A8I5QJT9 ENST00000346322.10 [Q15746-4] A0A8I5KYB9 ENST00000515434.1 Q15746 ENST00000418370.6 [Q15746-8] A0A8I5KU53 A0A8I5KS78 ENST00000685744.1 [Q15746-10] A0A8I5KUH4 A0A8I5KYZ0 Q3B765 D6R9C2 ENST00000685953.1 F8WBL7 ENST00000692352.1 Q06S79 A0A8I5KVV3 Q05B98 A0A8I5KUP2 ENST00000508240.2 [Q15746-9] ENST00000689227.1 ENST00000685665.1 A0A8I5KYA1 Q05B97 ENST00000583087.6 [Q15746-8] A0A8I5KUB2 A0A8I5QKL9 ENST00000510571.2 ENST00000685259.1 A0A8I5KXG8 ENST00000508240 ENST00000693689.1 [Q15746-2] ENST00000687434.1 ENST00000360772.7 [Q15746-3] ENST00000687848.1 ENST00000690457.1 A0A8I5KZ33 ENST00000688024.1 [Q15746-11]

MYLK report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review