I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| cardiac muscle cell | 7 studies | 69% ± 15% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| cardiac muscle cell | 7 studies | 69% ± 15% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| heart | 7 studies | 30% ± 14% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| ureter | 0% | 0 | 0 / 0 | 100% | 9.06 | 1 / 1 |
| brain | 4% | 120.09 | 107 / 2642 | 96% | 18.96 | 676 / 705 |
| heart | 100% | 657248.35 | 860 / 861 | 0% | 0 | 0 / 0 |
| muscle | 100% | 897295.32 | 801 / 803 | 0% | 0 | 0 / 0 |
| adrenal gland | 1% | 159.38 | 2 / 258 | 43% | 1.53 | 99 / 230 |
| pancreas | 22% | 526.22 | 72 / 328 | 12% | 0.28 | 21 / 178 |
| eye | 0% | 0 | 0 / 0 | 33% | 0.71 | 26 / 80 |
| prostate | 10% | 4535.02 | 24 / 245 | 13% | 40.62 | 63 / 502 |
| tonsil | 0% | 0 | 0 / 0 | 18% | 14.36 | 8 / 45 |
| lymph node | 0% | 0 | 0 / 0 | 14% | 0.29 | 4 / 29 |
| skin | 2% | 411.27 | 30 / 1809 | 8% | 0.17 | 37 / 472 |
| thymus | 4% | 278.73 | 25 / 653 | 4% | 1.27 | 24 / 605 |
| peripheral blood | 6% | 929.84 | 57 / 929 | 0% | 0 | 0 / 0 |
| lung | 4% | 518.19 | 24 / 578 | 1% | 0.41 | 12 / 1155 |
| uterus | 1% | 35.61 | 1 / 170 | 5% | 7.99 | 21 / 459 |
| breast | 3% | 453.30 | 14 / 459 | 2% | 1.16 | 19 / 1118 |
| ovary | 0% | 0 | 0 / 180 | 4% | 0.12 | 19 / 430 |
| blood vessel | 4% | 2669.45 | 57 / 1335 | 0% | 0 | 0 / 0 |
| adipose | 3% | 213.81 | 37 / 1204 | 0% | 0 | 0 / 0 |
| esophagus | 2% | 294.75 | 34 / 1445 | 0% | 0 | 0 / 183 |
| liver | 1% | 38.71 | 3 / 226 | 1% | 0.02 | 3 / 406 |
| intestine | 1% | 50.49 | 12 / 966 | 1% | 0.02 | 4 / 527 |
| bladder | 0% | 0 | 0 / 21 | 2% | 0.03 | 9 / 504 |
| stomach | 1% | 34.72 | 3 / 359 | 1% | 0.02 | 2 / 286 |
| kidney | 1% | 43.12 | 1 / 89 | 0% | 0.01 | 3 / 901 |
| spleen | 0% | 7.63 | 1 / 241 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0006941 | Biological process | striated muscle contraction |
| GO_0031449 | Biological process | regulation of slow-twitch skeletal muscle fiber contraction |
| GO_0003009 | Biological process | skeletal muscle contraction |
| GO_0014898 | Biological process | cardiac muscle hypertrophy in response to stress |
| GO_0002026 | Biological process | regulation of the force of heart contraction |
| GO_0002027 | Biological process | regulation of heart rate |
| GO_0006936 | Biological process | muscle contraction |
| GO_0046034 | Biological process | ATP metabolic process |
| GO_0060048 | Biological process | cardiac muscle contraction |
| GO_0055010 | Biological process | ventricular cardiac muscle tissue morphogenesis |
| GO_0014883 | Biological process | transition between fast and slow fiber |
| GO_0007512 | Biological process | adult heart development |
| GO_0045214 | Biological process | sarcomere organization |
| GO_0014728 | Biological process | regulation of the force of skeletal muscle contraction |
| GO_0030049 | Biological process | muscle filament sliding |
| GO_0005859 | Cellular component | muscle myosin complex |
| GO_0032982 | Cellular component | myosin filament |
| GO_0030018 | Cellular component | Z disc |
| GO_0030016 | Cellular component | myofibril |
| GO_0001725 | Cellular component | stress fiber |
| GO_0030017 | Cellular component | sarcomere |
| GO_0016460 | Cellular component | myosin II complex |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0016459 | Cellular component | myosin complex |
| GO_0051015 | Molecular function | actin filament binding |
| GO_0000146 | Molecular function | microfilament motor activity |
| GO_0005524 | Molecular function | ATP binding |
| GO_0005516 | Molecular function | calmodulin binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | MYH7 |
| Protein name | Mutant cardiac beta myosin heavy chain Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta) Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (Myosin heavy chain, cardiac muscle beta isoform) Myosin heavy chain 7 Beta myosin heavy chain cardiac isoform Beta-myosin heavy chain Cardiac muscle myosin heavy chain 7 beta Myosin heavy chain beta-subunit MYH7 Myosin 7 |
| Synonyms | MYHCB |
| Description | FUNCTION: Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. . FUNCTION: Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. . FUNCTION: Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. . |
| Accessions | A8CLL2 A0A191TDH1 A0A1B1HY26 A0A7R6M6S9 A0A1B1HY29 A0A7R6M6S4 A6N933 L0L1K4 A5YM51 A0A1B1HY13 L0L5E6 A0A1B1HY30 P12883 A0A191TDH2 A6N931 ENST00000355349.4 A8CLN2 Q14905 Q5GJ54 A8CLK2 A6N930 A0A7R6M6T2 |
