Insufficient scRNA-seq data for expression of MUTYH at tissue level.
Tissue | GTEx Coverage  | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| ovary | 100% | 1187.90 | 180 / 180 | 13% | 0.18 | 58 / 430 |
| esophagus | 100% | 707.41 | 1445 / 1445 | 8% | 0.09 | 14 / 183 |
| stomach | 100% | 691.72 | 359 / 359 | 7% | 0.09 | 19 / 286 |
| intestine | 100% | 963.09 | 966 / 966 | 6% | 0.09 | 34 / 527 |
| bladder | 100% | 939.62 | 21 / 21 | 5% | 0.07 | 23 / 504 |
| brain | 100% | 849.31 | 2638 / 2642 | 5% | 0.07 | 32 / 705 |
| lung | 100% | 767.29 | 576 / 578 | 4% | 0.06 | 46 / 1155 |
| skin | 100% | 724.64 | 1809 / 1809 | 3% | 0.03 | 12 / 472 |
| breast | 100% | 911.18 | 459 / 459 | 2% | 0.03 | 24 / 1118 |
| thymus | 100% | 1416.36 | 653 / 653 | 1% | 0.02 | 8 / 605 |
| uterus | 100% | 1210.52 | 170 / 170 | 1% | 0.02 | 5 / 459 |
| kidney | 100% | 975.21 | 89 / 89 | 1% | 0.02 | 9 / 901 |
| liver | 100% | 490.35 | 226 / 226 | 1% | 0.01 | 4 / 406 |
| prostate | 100% | 1182.66 | 245 / 245 | 1% | 0.01 | 3 / 502 |
| pancreas | 100% | 497.17 | 328 / 328 | 1% | 0.02 | 1 / 178 |
| adipose | 100% | 754.74 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| adrenal gland | 100% | 693.19 | 258 / 258 | 0% | 0 | 0 / 230 |
| spleen | 100% | 1486.97 | 241 / 241 | 0% | 0 | 0 / 0 |
| blood vessel | 100% | 692.37 | 1334 / 1335 | 0% | 0 | 0 / 0 |
| heart | 98% | 373.35 | 845 / 861 | 0% | 0 | 0 / 0 |
| muscle | 98% | 388.86 | 785 / 803 | 0% | 0 | 0 / 0 |
| peripheral blood | 89% | 547.20 | 829 / 929 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 3% | 0.04 | 1 / 29 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 80 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 45 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0006281 | Biological process | DNA repair |
| GO_0045007 | Biological process | depurination |
| GO_0060546 | Biological process | negative regulation of necroptotic process |
| GO_0006284 | Biological process | base-excision repair |
| GO_0006298 | Biological process | mismatch repair |
| GO_0005739 | Cellular component | mitochondrion |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0005634 | Cellular component | nucleus |
| GO_0034039 | Molecular function | 8-oxo-7,8-dihydroguanine DNA N-glycosylase activity |
| GO_0035485 | Molecular function | adenine/guanine mispair binding |
| GO_0019104 | Molecular function | DNA N-glycosylase activity |
| GO_0032407 | Molecular function | MutSalpha complex binding |
| GO_0032405 | Molecular function | MutLalpha complex binding |
| GO_0046872 | Molecular function | metal ion binding |
| GO_0032357 | Molecular function | oxidized purine DNA binding |
| GO_0000701 | Molecular function | purine-specific mismatch base pair DNA N-glycosylase activity |
| GO_0005515 | Molecular function | protein binding |
| GO_0051539 | Molecular function | 4 iron, 4 sulfur cluster binding |
| GO_0032408 | Molecular function | MutSbeta complex binding |
| GO_0032406 | Molecular function | MutLbeta complex binding |
| Gene name | MUTYH |
| Protein name | MutY-like protein isoform 3 MUTYH MutY DNA glycosylase Adenine DNA glycosylase (EC 3.2.2.31) Adenine DNA glycosylase (EC 3.2.2.31) (MutY homolog) (hMYH) |
| Synonyms | hCG_1780049 MYH |
| Description | FUNCTION: Involved in oxidative DNA damage repair. Initiates repair of A*oxoG to C*G by removing the inappropriately paired adenine base from the DNA backbone. Possesses both adenine and 2-OH-A DNA glycosylase activities. . FUNCTION: Adenine glycosylase active on G-A mispairs. . FUNCTION: Adenine glycosylase active on G-A mispairs. . FUNCTION: Adenine glycosylase active on G-A mispairs. . FUNCTION: Adenine glycosylase active on G-A mispairs. . FUNCTION: Adenine glycosylase active on G-A mispairs. . FUNCTION: Adenine glycosylase active on G-A mispairs. . FUNCTION: Adenine glycosylase active on G-A mispairs. . FUNCTION: Adenine glycosylase active on G-A mispairs. . FUNCTION: Adenine glycosylase active on G-A mispairs. . FUNCTION: Adenine glycosylase active on G-A mispairs. . |
| Accessions | ENST00000528013.6 ENST00000456914.7 [Q9UIF7-6] ENST00000485271.6 ENST00000531105.5 ENST00000672818.3 [Q9UIF7-1] ENST00000672011.1 E9PP30 E9PI11 H0YCA8 E9PLT4 ENST00000467940.5 ENST00000672593.1 ENST00000525160.5 ENST00000672314.2 [Q9UIF7-6] ENST00000673134.1 ENST00000710952.1 ENST00000354383.10 [Q9UIF7-5] H0YEI2 A0A0S2Z4D0 A0A5F9ZI60 ENST00000470256.5 ENST00000475516.5 Q9UIF7 Q5T418 H0YER6 ENST00000372104.5 [Q9UIF7-6] H0YCY5 E5KP28 ENST00000529892.6 ENST00000674679.2 ENST00000529984.5 ENST00000435155.1 A0A2S1WCK4 E5KP26 E9PKM9 ENST00000461495.6 E9PM53 ENST00000448481.5 [Q9UIF7-4] ENST00000483127.2 Q5T413 A0A6Q8PF38 ENST00000372115.7 [Q9UIF7-3] E5KP27 E9PNY0 E9PIW5 E9PP34 ENST00000467459.6 ENST00000355498.6 [Q9UIF7-6] E9PMH1 ENST00000372098.7 [Q9UIF7-1] ENST00000488731.6 ENST00000481571.5 ENST00000533178.6 ENST00000672764.1 A0A5F9ZHI2 ENST00000372110.7 [Q9UIF7-2] ENST00000435155.2 [Q9UIF7-4] ENST00000412971.6 A0A5F9ZI14 ENST00000672314.1 |
