MUC4 | OmnibusX

Name	Number of supported studies	Average coverage
ciliated cell	15 studies	51% ± 17%	Explore
club cell	9 studies	38% ± 19%	Explore
basal cell	8 studies	35% ± 12%	Explore
epithelial cell	7 studies	42% ± 19%	Explore
respiratory goblet cell	7 studies	69% ± 8%	Explore
secretory cell	7 studies	46% ± 17%	Explore
goblet cell	7 studies	44% ± 14%	Explore
deuterosomal cell	4 studies	53% ± 18%	Explore
squamous epithelial cell	4 studies	69% ± 13%	Explore
duct epithelial cell	3 studies	39% ± 24%	Explore
hillock cell	3 studies	35% ± 12%	Explore
mucus secreting cell	3 studies	29% ± 4%	Explore
transit amplifying cell	3 studies	18% ± 2%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	3 studies	54% ± 3%	Explore
intestine	3 studies	18% ± 1%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
lung	93%	2142.70	540 / 578	68%	19.35	780 / 1155
intestine	73%	8206.45	710 / 966	68%	17.35	359 / 527
prostate	93%	7361.08	227 / 245	23%	1.80	113 / 502
esophagus	49%	3400.20	702 / 1445	60%	27.45	110 / 183
stomach	51%	1093.13	182 / 359	53%	10.31	152 / 286
ureter	0%	0	0 / 0	100%	3.57	1 / 1
pancreas	14%	34.92	45 / 328	65%	12.76	116 / 178
uterus	21%	220.33	35 / 170	57%	37.93	261 / 459
kidney	73%	228.28	65 / 89	4%	0.17	32 / 901
tonsil	0%	0	0 / 0	69%	36.80	31 / 45
ovary	40%	88.32	72 / 180	24%	2.86	105 / 430
bladder	14%	352.86	3 / 21	41%	9.68	205 / 504
thymus	30%	60.05	194 / 653	4%	0.48	26 / 605
breast	29%	322.40	135 / 459	2%	0.31	21 / 1118
brain	24%	46.79	626 / 2642	0%	0.02	3 / 705
liver	12%	19.54	27 / 226	1%	0.08	3 / 406
skin	8%	13.65	138 / 1809	0%	0.01	1 / 472
adipose	7%	15.44	87 / 1204	0%	0	0 / 0
spleen	4%	8.38	9 / 241	0%	0	0 / 0
muscle	3%	5.20	27 / 803	0%	0	0 / 0
peripheral blood	3%	18.87	30 / 929	0%	0	0 / 0
blood vessel	2%	4.26	33 / 1335	0%	0	0 / 0
adrenal gland	2%	4.83	4 / 258	0%	0.03	1 / 230
heart	1%	1.80	11 / 861	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
eye	0%	0	0 / 0	0%	0	0 / 80
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

IV. Literature review

[source]

Gene name	MUC4
Protein name	Mucin 4, cell surface associated Mucin-4 Mucin Mucin-4 (MUC-4) (Ascites sialoglycoprotein) (ASGP) (Pancreatic adenocarcinoma mucin) (Testis mucin) (Tracheobronchial mucin) [Cleaved into: Mucin-4 alpha chain (Ascites sialoglycoprotein 1) (ASGP-1); Mucin-4 beta chain (Ascites sialoglycoprotein 2) (ASGP-2)] Mucin 4, cell surface associated (Mucin-4) Mucin 4
Synonyms
Description	FUNCTION: Membrane-bound mucin, a family of highly glycosylated proteins that constitute the major component of the mucus, the slimy and viscous secretion covering epithelial surfaces . These glycoproteins play important roles in the protection of the epithelium and are implicated in epithelial renewal and differentiation . Regulates cellular behavior through both anti-adhesive effects on cell-cell and cell-extracellular matrix interactions and its ability to act as an intramembrane ligand for ERBB2. Plays an important role in proliferation and differentiation of epithelial cells by inducing specific phosphorylation of ERBB2. In polarized epithelial cells, segregates ERBB2 and other ERBB receptors and prevents ERBB2 from acting as a coreceptor. The interaction with ERBB2 leads to enhanced expression of CDKN1B. The formation of a MUC4-ERBB2-ERBB3-NRG1 complex leads to down-regulation of CDKN1B, resulting in repression of apoptosis and stimulation of proliferation. Its ability to promote tumor growth may be mainly due to repression of apoptosis as opposed to proliferation. .
Accessions	ENST00000308466.12 ENST00000339251.9 ENST00000629882.2 ENST00000630081.2 ENST00000627218.2 A0A0G2JRU8 ENST00000621966.4 Q99102 ENST00000630966.2 ENST00000626113.2 E7EQT2 A0A0G2JS91 A0A0G2JLU8 ENST00000630579.2 ENST00000630616.2 A0A0G2JQN9 ENST00000629031.2 A0A0G2JR46 ENST00000631081.2 ENST00000629947.2 A0A0G2JNJ5 ENST00000629076.2 ENST00000626664.2 A0A0G2JSC3 ENST00000627236.2 ENST00000614666.3 ENST00000477086 A0A0G2JN54 ENST00000617794.2 A0A0G2JMX1 ENST00000613841.4 ENST00000478156.5 [Q99102-3] ENST00000615271.1 ENST00000625421.2 E9PDY6 ENST00000625430.2 ENST00000628685.2 A0A0G2JNG3 A0A0G2JRC8 ENST00000628970.2 ENST00000627391.2 ENST00000629929.2 ENST00000631180.2 A0A0G2JQC6 A0A0G2JRS2 ENST00000619175.3 ENST00000628931.2 O75456 ENST00000629154.2 A0A0G2JQI2 ENST00000629001.2 ENST00000346145.8 [Q99102-13] ENST00000628806.2 ENST00000470451.5 [Q99102-7] ENST00000631097.2 ENST00000349607.8 [Q99102-12] ENST00000627062.2 ENST00000625238.2 ENST00000618211.1 A0A0G2JRK4 ENST00000631360.2 A0A0G2JNL3 ENST00000627476.2 ENST00000631008.2 ENST00000627411.2 ENST00000626390.2 ENST00000629163.2 ENST00000475231.5 [Q99102-10] ENST00000626248.2 ENST00000629594.2 A0A0G2JSB1 ENST00000630459.2 A0A0G2JSB4 ENST00000630769.2 ENST00000480843.5 ENST00000628062.2 A0A0G2JQT8 E7ENC5 A0A0G2JRJ6 ENST00000625407.2 A0A0G2JSD9 ENST00000631201.2 ENST00000466475.5 ENST00000620934.1 A0A0G2JQA9 ENST00000627603.2 ENST00000626242.2 H0Y2Y1 ENST00000629826.2 ENST00000475231 ENST00000630643.2 H7BZI3 ENST00000625485.2 E7EW47 ENST00000626305.2 ENST00000629775.2 H7BXN7 ENST00000629873.2 ENST00000478156 ENST00000625520.2 A0A0G2JSE4 ENST00000627334.2 Q9UP82 ENST00000618077.1 A0A0G2JRD8 A0A0G2JRW3 ENST00000477756.5 ENST00000627577.2 ENST00000628045.2 A0A0G2JQK9 A0A0G2JQC1 ENST00000463781.8 [Q99102-1] ENST00000631279.2 ENST00000612476.3 ENST00000630325.2 E7ERK0 ENST00000626727.2 ENST00000477086.5 [Q99102-2] ENST00000628987.2 ENST00000627295.2 ENST00000631127.2 ENST00000627791.2 ENST00000627153.2 A0A0G2JS19 ENST00000627165.2 ENST00000639126.1 ENST00000619402.4 A0A0G2JRW6 ENST00000629790.2 A0A0G2JS42 ENST00000629021.2 ENST00000627007.2 ENST00000631334.2 ENST00000629801.2 ENST00000627276.2 ENST00000630176.2 ENST00000629006.2 A0A0G2JRY3 A0A0G2JRT1 ENST00000628818.2 E7EWN1 ENST00000631146.1 ENST00000613615.1 ENST00000626947.2 ENST00000628330.2 A0A0G2JNM3 E7EUL9 A0A0G2JR97 ENST00000612796.3 ENST00000626364.2 ENST00000628366.2 E7ETT5 A0A0G2JS65 A0A0G2JRV5 A0A0G2JM16 Q9UK75 ENST00000630183.2 ENST00000626164.2 A0A0G2JRE6 ENST00000628456.1 A0A0G2JQJ2 ENST00000626427.2 ENST00000626905.2 ENST00000630037.2 ENST00000610962.3 A0A0G2JR58 ENST00000630917.2 ENST00000626878.2 A0A0G2JPA4 ENST00000463781 ENST00000625840.2 ENST00000617056.4 ENST00000612020.2 ENST00000462323.5 ENST00000631351.2 ENST00000415455.5 ENST00000627017.2 ENST00000629793.2 ENST00000470451 ENST00000631078.2 ENST00000627146.2 ENST00000631069.2 ENST00000627203.2 ENST00000448861.5 ENST00000630127.2 ENST00000479406.5 O76037 ENST00000630258.2 E7EQG8 ENST00000626318.2 ENST00000392407.6 ENST00000628289.2 A0A0G2JRA1 A0A0G2JR43

GO_0030277	Biological process	maintenance of gastrointestinal epithelium
GO_0007160	Biological process	cell-matrix adhesion
GO_0005615	Cellular component	extracellular space
GO_0005796	Cellular component	Golgi lumen
GO_0070062	Cellular component	extracellular exosome
GO_0005886	Cellular component	plasma membrane
GO_0031982	Cellular component	vesicle
GO_0031012	Cellular component	extracellular matrix
GO_0016020	Cellular component	membrane
GO_0030197	Molecular function	extracellular matrix constituent, lubricant activity
GO_0005176	Molecular function	ErbB-2 class receptor binding

MUC4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review