Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 15 studies | 29% ± 15% | |
microglial cell | 13 studies | 54% ± 17% | |
astrocyte | 12 studies | 33% ± 13% | |
fibroblast | 11 studies | 30% ± 10% | |
oligodendrocyte precursor cell | 10 studies | 28% ± 11% | |
glutamatergic neuron | 9 studies | 43% ± 23% | |
GABAergic neuron | 8 studies | 38% ± 21% | |
macrophage | 6 studies | 33% ± 10% | |
endothelial cell of lymphatic vessel | 6 studies | 28% ± 10% | |
dendritic cell | 6 studies | 18% ± 2% | |
myeloid cell | 6 studies | 20% ± 7% | |
smooth muscle cell | 6 studies | 28% ± 9% | |
neuron | 5 studies | 33% ± 16% | |
interneuron | 5 studies | 42% ± 22% | |
epithelial cell | 5 studies | 25% ± 8% | |
mesothelial cell | 4 studies | 26% ± 6% | |
retinal cone cell | 4 studies | 54% ± 9% | |
GABAergic interneuron | 3 studies | 19% ± 0% | |
Mueller cell | 3 studies | 20% ± 6% | |
alveolar macrophage | 3 studies | 32% ± 6% | |
granule cell | 3 studies | 42% ± 11% | |
oligodendrocyte | 3 studies | 31% ± 12% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
lung | 100% | 2220.05 | 576 / 578 | 100% | 27.19 | 1152 / 1155 |
ovary | 100% | 1754.05 | 180 / 180 | 99% | 20.13 | 424 / 430 |
thymus | 97% | 812.57 | 635 / 653 | 99% | 22.08 | 597 / 605 |
brain | 90% | 1166.42 | 2376 / 2642 | 100% | 20.72 | 704 / 705 |
kidney | 96% | 1113.60 | 85 / 89 | 94% | 16.68 | 848 / 901 |
skin | 88% | 2223.16 | 1591 / 1809 | 100% | 42.77 | 471 / 472 |
uterus | 88% | 822.31 | 149 / 170 | 100% | 29.96 | 457 / 459 |
adrenal gland | 100% | 1406.27 | 258 / 258 | 83% | 12.16 | 191 / 230 |
pancreas | 84% | 616.20 | 275 / 328 | 99% | 22.31 | 176 / 178 |
breast | 94% | 876.14 | 432 / 459 | 87% | 15.57 | 978 / 1118 |
intestine | 81% | 646.22 | 783 / 966 | 99% | 32.56 | 522 / 527 |
bladder | 76% | 934.62 | 16 / 21 | 99% | 28.83 | 499 / 504 |
stomach | 62% | 457.87 | 224 / 359 | 99% | 28.59 | 283 / 286 |
esophagus | 59% | 488.72 | 854 / 1445 | 99% | 27.49 | 182 / 183 |
prostate | 76% | 658.76 | 185 / 245 | 81% | 8.77 | 406 / 502 |
eye | 0% | 0 | 0 / 0 | 100% | 59.40 | 80 / 80 |
lymph node | 0% | 0 | 0 / 0 | 100% | 35.32 | 29 / 29 |
spleen | 100% | 1228.50 | 241 / 241 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 100% | 12.99 | 1 / 1 |
blood vessel | 100% | 3998.87 | 1331 / 1335 | 0% | 0 | 0 / 0 |
liver | 37% | 276.32 | 83 / 226 | 59% | 7.14 | 241 / 406 |
tonsil | 0% | 0 | 0 / 0 | 96% | 22.78 | 43 / 45 |
adipose | 95% | 1157.25 | 1147 / 1204 | 0% | 0 | 0 / 0 |
heart | 59% | 585.78 | 511 / 861 | 0% | 0 | 0 / 0 |
peripheral blood | 33% | 1133.74 | 304 / 929 | 0% | 0 | 0 / 0 |
muscle | 4% | 19.58 | 29 / 803 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0015942 | Biological process | formate metabolic process |
GO_0006760 | Biological process | folic acid-containing compound metabolic process |
GO_0048703 | Biological process | embryonic viscerocranium morphogenesis |
GO_0009257 | Biological process | 10-formyltetrahydrofolate biosynthetic process |
GO_0035999 | Biological process | tetrahydrofolate interconversion |
GO_0001843 | Biological process | neural tube closure |
GO_0048702 | Biological process | embryonic neurocranium morphogenesis |
GO_0005829 | Cellular component | cytosol |
GO_0016020 | Cellular component | membrane |
GO_0005759 | Cellular component | mitochondrial matrix |
GO_0005739 | Cellular component | mitochondrion |
GO_0042803 | Molecular function | protein homodimerization activity |
GO_0004488 | Molecular function | methylenetetrahydrofolate dehydrogenase (NADP+) activity |
GO_0004329 | Molecular function | formate-tetrahydrofolate ligase activity |
GO_0005524 | Molecular function | ATP binding |
Gene name | MTHFD1L |
Protein name | Monofunctional C1-tetrahydrofolate synthase, mitochondrial (EC 6.3.4.3) (Formyltetrahydrofolate synthetase) Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like formate--tetrahydrofolate ligase (EC 6.3.4.3) |
Synonyms | FTHFSDC1 |
Description | FUNCTION: May provide the missing metabolic reaction required to link the mitochondria and the cytoplasm in the mammalian model of one-carbon folate metabolism complementing thus the enzymatic activities of MTHFD2. . |
Accessions | Q5JYA8 Q4VXV2 A0A087WVM4 ENST00000367308.8 B7ZM99 ENST00000618312.4 Q5JYA3 ENST00000453602.1 ENST00000367321.8 [Q6UB35-1] ENST00000611279.4 ENST00000441122.5 ENST00000367307.8 [Q6UB35-2] ENST00000420192.1 Q4VXM0 ENST00000450635.1 ENST00000423867.2 Q4VXM1 Q6UB35 H0Y327 |