MTHFD1L report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0015942Biological processformate metabolic process
GO_0006760Biological processfolic acid-containing compound metabolic process
GO_0048703Biological processembryonic viscerocranium morphogenesis
GO_0009257Biological process10-formyltetrahydrofolate biosynthetic process
GO_0035999Biological processtetrahydrofolate interconversion
GO_0001843Biological processneural tube closure
GO_0048702Biological processembryonic neurocranium morphogenesis
GO_0005829Cellular componentcytosol
GO_0016020Cellular componentmembrane
GO_0005759Cellular componentmitochondrial matrix
GO_0005739Cellular componentmitochondrion
GO_0042803Molecular functionprotein homodimerization activity
GO_0004488Molecular functionmethylenetetrahydrofolate dehydrogenase (NADP+) activity
GO_0004329Molecular functionformate-tetrahydrofolate ligase activity
GO_0005524Molecular functionATP binding

IV. Literature review

[source]
Gene nameMTHFD1L
Protein nameMonofunctional C1-tetrahydrofolate synthase, mitochondrial (EC 6.3.4.3) (Formyltetrahydrofolate synthetase)
Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like
formate--tetrahydrofolate ligase (EC 6.3.4.3)
SynonymsFTHFSDC1
DescriptionFUNCTION: May provide the missing metabolic reaction required to link the mitochondria and the cytoplasm in the mammalian model of one-carbon folate metabolism complementing thus the enzymatic activities of MTHFD2. .

AccessionsQ5JYA8
Q4VXV2
A0A087WVM4
ENST00000367308.8
B7ZM99
ENST00000618312.4
Q5JYA3
ENST00000453602.1
ENST00000367321.8 [Q6UB35-1]
ENST00000611279.4
ENST00000441122.5
ENST00000367307.8 [Q6UB35-2]
ENST00000420192.1
Q4VXM0
ENST00000450635.1
ENST00000423867.2
Q4VXM1
Q6UB35
H0Y327