I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| GABAergic neuron | 3 studies | 19% ± 3% | |
| glutamatergic neuron | 3 studies | 31% ± 6% | |
| astrocyte | 3 studies | 23% ± 10% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| GABAergic neuron | 3 studies | 19% ± 3% | |
| glutamatergic neuron | 3 studies | 31% ± 6% | |
| astrocyte | 3 studies | 23% ± 10% |
Insufficient scRNA-seq data for expression of MTBP at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| esophagus | 99% | 154.31 | 1428 / 1445 | 99% | 5.27 | 182 / 183 |
| ovary | 100% | 254.51 | 180 / 180 | 97% | 4.07 | 418 / 430 |
| uterus | 100% | 247.19 | 170 / 170 | 96% | 4.82 | 439 / 459 |
| breast | 100% | 231.99 | 457 / 459 | 96% | 4.26 | 1069 / 1118 |
| stomach | 99% | 119.31 | 355 / 359 | 93% | 3.54 | 267 / 286 |
| intestine | 100% | 163.63 | 963 / 966 | 92% | 3.18 | 487 / 527 |
| bladder | 100% | 147.52 | 21 / 21 | 92% | 3.30 | 464 / 504 |
| skin | 100% | 303.77 | 1800 / 1809 | 88% | 2.93 | 415 / 472 |
| lung | 88% | 130.27 | 507 / 578 | 92% | 3.46 | 1062 / 1155 |
| brain | 97% | 311.49 | 2558 / 2642 | 81% | 2.00 | 568 / 705 |
| pancreas | 92% | 80.70 | 303 / 328 | 65% | 1.35 | 115 / 178 |
| prostate | 99% | 153.49 | 243 / 245 | 56% | 0.90 | 281 / 502 |
| adrenal gland | 96% | 108.80 | 247 / 258 | 58% | 0.96 | 134 / 230 |
| thymus | 98% | 128.62 | 643 / 653 | 39% | 0.80 | 234 / 605 |
| kidney | 87% | 95.99 | 77 / 89 | 43% | 0.71 | 389 / 901 |
| liver | 62% | 40.46 | 141 / 226 | 39% | 0.78 | 158 / 406 |
| spleen | 100% | 218.96 | 241 / 241 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 100% | 1.48 | 1 / 1 |
| blood vessel | 99% | 159.49 | 1324 / 1335 | 0% | 0 | 0 / 0 |
| adipose | 99% | 198.67 | 1194 / 1204 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 98% | 5.11 | 44 / 45 |
| lymph node | 0% | 0 | 0 / 0 | 79% | 3.07 | 23 / 29 |
| heart | 79% | 65.30 | 677 / 861 | 0% | 0 | 0 / 0 |
| muscle | 76% | 58.70 | 611 / 803 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 48% | 1.39 | 38 / 80 |
| peripheral blood | 37% | 193.30 | 345 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0034501 | Biological process | protein localization to kinetochore |
| GO_0008285 | Biological process | negative regulation of cell population proliferation |
| GO_0007089 | Biological process | traversing start control point of mitotic cell cycle |
| GO_0045839 | Biological process | negative regulation of mitotic nuclear division |
| GO_0031396 | Biological process | regulation of protein ubiquitination |
| GO_0000776 | Cellular component | kinetochore |
| GO_0000785 | Cellular component | chromatin |
| Gene name | MTBP |
| Protein name | Mdm2-binding protein (hMTBP) MDM2 binding protein |
| Synonyms | |
| Description | FUNCTION: Inhibits cell migration in vitro and suppresses the invasive behavior of tumor cells (By similarity). May play a role in MDM2-dependent p53/TP53 homeostasis in unstressed cells. Inhibits autoubiquitination of MDM2, thereby enhancing MDM2 stability. This promotes MDM2-mediated ubiquitination of p53/TP53 and its subsequent degradation. . |
| Accessions | ENST00000305949.6 [Q96DY7-1] ENST00000519556.1 ENST00000523373.5 [Q96DY7-3] Q96DY7 H0YB28 |
