MTARC2 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of MTARC2 at tissue level.

III. Associated gene sets

GO_0070458Biological processcellular detoxification of nitrogen compound
GO_0042126Biological processnitrate metabolic process
GO_0006809Biological processnitric oxide biosynthetic process
GO_0051410Biological processdetoxification of nitrogen compound
GO_0005741Cellular componentmitochondrial outer membrane
GO_0005777Cellular componentperoxisome
GO_0005739Cellular componentmitochondrion
GO_0016661Molecular functionoxidoreductase activity, acting on other nitrogenous compounds as donors
GO_0098809Molecular functionnitrite reductase activity
GO_0043546Molecular functionmolybdopterin cofactor binding
GO_0030170Molecular functionpyridoxal phosphate binding
GO_0030151Molecular functionmolybdenum ion binding
GO_0008940Molecular functionnitrate reductase activity

IV. Literature review

[source]
Gene nameMTARC2
Protein nameMitochondrial amidoxime reducing component 2
Mitochondrial amidoxime reducing component 2 (mARC2) (EC 1.7.-.-) (Molybdenum cofactor sulfurase C-terminal domain-containing protein 2) (MOSC domain-containing protein 2) (Moco sulfurase C-terminal domain-containing protein 2)
SynonymsMARC2
MOSC2
DescriptionFUNCTION: Catalyzes the reduction of N-oxygenated molecules, acting as a counterpart of cytochrome P450 and flavin-containing monooxygenases in metabolic cycles . As a component of prodrug-converting system, reduces a multitude of N-hydroxylated prodrugs particularly amidoximes, leading to increased drug bioavailability . May be involved in mitochondrial N(omega)-hydroxy-L-arginine (NOHA) reduction, regulating endogenous nitric oxide levels and biosynthesis . Postulated to cleave the N-OH bond of N-hydroxylated substrates in concert with electron transfer from NADH to cytochrome b5 reductase then to cytochrome b5, the ultimate electron donor that primes the active site for substrate reduction . .

AccessionsENST00000425560.1
X1WI34
ENST00000469583.1
ENST00000366913.8 [Q969Z3-1]
Q969Z3
ENST00000359316.6 [Q969Z3-2]
F6V6Z1