MTAP report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006139Biological processnucleobase-containing compound metabolic process
GO_0019509Biological processL-methionine salvage from methylthioadenosine
GO_0033574Biological processresponse to testosterone
GO_0006738Biological processnicotinamide riboside catabolic process
GO_0032259Biological processmethylation
GO_0006166Biological processpurine ribonucleoside salvage
GO_0070062Cellular componentextracellular exosome
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0004645Molecular function1,4-alpha-oligoglucan phosphorylase activity
GO_0017061Molecular functionS-methyl-5-thioadenosine phosphorylase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameMTAP
Protein nameAlternative protein MTAP
S-methyl-5'-thioadenosine phosphorylase (EC 2.4.2.28) (5'-methylthioadenosine phosphorylase) (MTA phosphorylase) (MTAP) (MTAPase)
MTAP
Methylthioadenosine phosphorylase
MTAP protein
Purine nucleoside phosphorylase (PNP) (EC 2.4.2.1)
SynonymsHEL-249
MTAP-ANRIL
fusion
MSAP
DescriptionFUNCTION: Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates. .

FUNCTION: Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates. .

FUNCTION: Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates. .

FUNCTION: Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates. .

FUNCTION: Purine nucleoside phosphorylase involved in purine salvage. .

FUNCTION: Purine nucleoside phosphorylase involved in purine salvage. .

FUNCTION: Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates. .

AccessionsENST00000580900.5 [Q13126-3]
J3KRN1
Q13126
Q6FHT1
A0A140CZL4
J3QSB7
Q9NRK7
ENST00000427788.2
L8E7D7
ENST00000419385.5
ENST00000580718.1
A0A2R8Y4K0
ENST00000577563.1
F8WES2
Q6FHP1
Q05DJ2
ENST00000460874.6
ENST00000644715.2 [Q13126-1]
B4DUC8
A0A384ME80