MT-RNR1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0032147Biological processactivation of protein kinase activity
GO_0033687Biological processosteoblast proliferation
GO_0048630Biological processskeletal muscle tissue growth
GO_0001649Biological processosteoblast differentiation
GO_0072522Biological processpurine-containing compound biosynthetic process
GO_0043610Biological processregulation of carbohydrate utilization
GO_0071902Biological processpositive regulation of protein serine/threonine kinase activity
GO_2001145Biological processnegative regulation of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0005615Cellular componentextracellular space
GO_0005739Cellular componentmitochondrion
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0140297Molecular functionDNA-binding transcription factor binding

IV. Literature review

[source]
Gene nameMT-RNR1
Protein nameMitochondrial-derived peptide MOTS-c (Mitochondrial open reading frame of the 12S rRNA-c)
Synonyms
DescriptionFUNCTION: Regulates insulin sensitivity and metabolic homeostasis . Inhibits the folate cycle, thereby reducing de novo purine biosynthesis which leads to the accumulation of the de novo purine synthesis intermediate 5-aminoimidazole-4-carboxamide (AICAR) and the activation of the metabolic regulator 5'-AMP-activated protein kinase (AMPK) . Protects against age-dependent and diet-induced insulin resistance as well as diet-induced obesity . In response to metabolic stress, translocates to the nucleus where it binds to antioxidant response elements (ARE) present in the promoter regions of a number of genes and plays a role in regulating nuclear gene expression in an NFE2L2-dependent manner and increasing cellular resistance to metabolic stress . Increases mitochondrial respiration and levels of CPT1A and cytokines IL1B, IL6, IL8, IL10 and TNF in senescent cells . Increases activity of the serine/threonine protein kinase complex mTORC2 and reduces activity of the PTEN phosphatase, thus promoting phosphorylation of AKT . This promotes AKT-mediated phosphorylation of transcription factor FOXO1 which reduces FOXO1 activity, leading to reduced levels of MSTN and promotion of skeletal muscle growth . Promotes osteogenic differentiation of bone marrow mesenchymal stem cells via the TGFB/SMAD pathway . Promotes osteoblast proliferation and osteoblast synthesis of type I collagens COL1A1 and COL1A2 via the TGFB/SMAD pathway . .

AccessionsA0A0C5B5G6