MSRB2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0030041Biological processactin filament polymerization
GO_0030091Biological processprotein repair
GO_0006979Biological processresponse to oxidative stress
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005739Cellular componentmitochondrion
GO_0033745Molecular functionL-methionine-(R)-S-oxide reductase activity
GO_0033743Molecular functionpeptide-methionine (R)-S-oxide reductase activity
GO_0005515Molecular functionprotein binding
GO_0003779Molecular functionactin binding
GO_0008270Molecular functionzinc ion binding

IV. Literature review

[source]
Gene nameMSRB2
Protein nameMethionine-R-sulfoxide reductase B2, mitochondrial (MsrB2) (EC 1.8.4.12) (EC 1.8.4.14)
Methionine sulfoxide reductase B2
Methionine sulfoxide reductase B2, isoform CRA_a (Methionine-r-sulfoxide reductase B2 variant 1)
SynonymsMSRB
CGI-131
CBS-1
hCG_23087
DescriptionFUNCTION: Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases, methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residue. Upon oxidative stress, may play a role in the preservation of mitochondrial integrity by decreasing the intracellular reactive oxygen species build-up through its scavenging role, hence contributing to cell survival and protein maintenance. .

AccessionsH0YE51
ENST00000376510.8
Q9Y3D2
ENST00000472663.1
A6NCQ5