MRGBP report

I. Expression across cell types

Insufficient scRNA-seq data for expression of MRGBP at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of MRGBP at tissue level.

III. Associated gene sets

GO_0006325Biological processchromatin organization
GO_0042981Biological processregulation of apoptotic process
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_2000779Biological processregulation of double-strand break repair
GO_0051726Biological processregulation of cell cycle
GO_1905168Biological processpositive regulation of double-strand break repair via homologous recombination
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0005654Cellular componentnucleoplasm
GO_0000786Cellular componentnucleosome
GO_0035267Cellular componentNuA4 histone acetyltransferase complex
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameMRGBP
Protein nameMRG/MORF4L-binding protein (MRG-binding protein) (Up-regulated in colon cancer 4) (Urcc4)
SynonymsC20orf20
DescriptionFUNCTION: Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage.

AccessionsQ9NV56
ENST00000370487.5