I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| epithelial cell | 4 studies | 20% ± 4% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| epithelial cell | 4 studies | 20% ± 4% |
Insufficient scRNA-seq data for expression of MPND at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| liver | 100% | 897.62 | 226 / 226 | 100% | 28.38 | 406 / 406 |
| pancreas | 100% | 494.17 | 328 / 328 | 100% | 18.00 | 178 / 178 |
| thymus | 100% | 649.21 | 653 / 653 | 100% | 21.61 | 605 / 605 |
| brain | 100% | 719.08 | 2639 / 2642 | 100% | 17.81 | 705 / 705 |
| ovary | 100% | 559.01 | 180 / 180 | 100% | 12.62 | 429 / 430 |
| uterus | 100% | 557.52 | 170 / 170 | 100% | 19.82 | 457 / 459 |
| esophagus | 100% | 572.62 | 1445 / 1445 | 99% | 10.78 | 182 / 183 |
| kidney | 100% | 788.90 | 89 / 89 | 99% | 18.78 | 896 / 901 |
| prostate | 100% | 851.01 | 245 / 245 | 99% | 33.19 | 499 / 502 |
| intestine | 100% | 887.02 | 966 / 966 | 99% | 23.15 | 522 / 527 |
| skin | 100% | 517.12 | 1808 / 1809 | 99% | 19.09 | 467 / 472 |
| bladder | 100% | 671.10 | 21 / 21 | 98% | 23.87 | 496 / 504 |
| lung | 100% | 574.18 | 578 / 578 | 98% | 15.81 | 1136 / 1155 |
| breast | 100% | 485.92 | 459 / 459 | 98% | 17.29 | 1093 / 1118 |
| stomach | 100% | 636.84 | 359 / 359 | 98% | 19.91 | 279 / 286 |
| adrenal gland | 100% | 825.79 | 258 / 258 | 97% | 13.93 | 223 / 230 |
| adipose | 100% | 451.31 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 100% | 27.91 | 80 / 80 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 32.56 | 29 / 29 |
| spleen | 100% | 645.47 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 20.61 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 20.82 | 1 / 1 |
| blood vessel | 100% | 466.06 | 1330 / 1335 | 0% | 0 | 0 / 0 |
| heart | 100% | 548.21 | 857 / 861 | 0% | 0 | 0 / 0 |
| muscle | 100% | 411.99 | 799 / 803 | 0% | 0 | 0 / 0 |
| peripheral blood | 99% | 490.05 | 917 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0006508 | Biological process | proteolysis |
| GO_0006302 | Biological process | double-strand break repair |
| GO_0070552 | Cellular component | BRISC complex |
| GO_0070531 | Cellular component | BRCA1-A complex |
| GO_0140492 | Molecular function | metal-dependent deubiquitinase activity |
| GO_0031593 | Molecular function | polyubiquitin modification-dependent protein binding |
| GO_0005515 | Molecular function | protein binding |
| GO_0046872 | Molecular function | metal ion binding |
| GO_0008237 | Molecular function | metallopeptidase activity |
| Gene name | MPND |
| Protein name | MPN domain-containing protein (EC 3.4.-.-) MPN domain containing |
| Synonyms | hCG_2004608 FLJ14981 |
| Description | FUNCTION: Probable protease (By similarity). Acts as a sensor of N(6)-methyladenosine methylation on DNA (m6A): recognizes and binds m6A DNA, leading to its degradation . . |
| Accessions | ENST00000597036.5 W4VSR2 M0QXK5 ENST00000594162.1 M0R044 M0R0F2 ENST00000601877.1 ENST00000596722.5 ENST00000599840.6 ENST00000594716.5 M0QXC4 Q8N594 ENST00000262966.12 [Q8N594-1] ENST00000359935.8 [Q8N594-2] M0R189 |
