MOV10L1 | OmnibusX

Name	Number of supported studies	Average coverage
glutamatergic neuron	3 studies	21% ± 4%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of MOV10L1 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
prostate	99%	249.37	242 / 245	44%	1.24	220 / 502
brain	98%	151.07	2598 / 2642	20%	0.33	140 / 705
uterus	96%	389.28	163 / 170	22%	1.18	102 / 459
ovary	99%	373.31	179 / 180	4%	0.10	18 / 430
lung	83%	85.50	482 / 578	13%	0.35	155 / 1155
thymus	93%	83.78	605 / 653	2%	0.05	14 / 605
intestine	92%	159.88	885 / 966	2%	0.03	12 / 527
breast	83%	66.16	380 / 459	5%	0.10	59 / 1118
adipose	88%	71.73	1054 / 1204	0%	0	0 / 0
blood vessel	87%	159.33	1163 / 1335	0%	0	0 / 0
esophagus	71%	45.83	1030 / 1445	14%	0.27	25 / 183
bladder	67%	61.90	14 / 21	6%	0.22	28 / 504
skin	65%	37.62	1171 / 1809	3%	0.15	16 / 472
kidney	62%	34.80	55 / 89	5%	0.09	47 / 901
heart	50%	40.03	432 / 861	0%	0	0 / 0
liver	37%	23.19	83 / 226	9%	0.18	38 / 406
stomach	36%	19.38	128 / 359	7%	0.14	20 / 286
pancreas	27%	11.50	87 / 328	10%	0.16	18 / 178
adrenal gland	18%	6.75	47 / 258	6%	0.16	14 / 230
tonsil	0%	0	0 / 0	16%	0.39	7 / 45
spleen	14%	4.89	33 / 241	0%	0	0 / 0
eye	0%	0	0 / 0	6%	0.10	5 / 80
peripheral blood	4%	1.78	38 / 929	0%	0	0 / 0
muscle	1%	0.97	11 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0034587	Biological process	piRNA processing
GO_0007283	Biological process	spermatogenesis
GO_0035194	Biological process	regulatory ncRNA-mediated post-transcriptional gene silencing
GO_0007141	Biological process	male meiosis I
GO_0007281	Biological process	germ cell development
GO_0141007	Biological process	siRNA-mediated retrotransposon silencing by heterochromatin formation
GO_0071546	Cellular component	pi-body
GO_0005829	Cellular component	cytosol
GO_0043186	Cellular component	P granule
GO_0005524	Molecular function	ATP binding
GO_0003724	Molecular function	RNA helicase activity
GO_0016887	Molecular function	ATP hydrolysis activity
GO_0000287	Molecular function	magnesium ion binding
GO_0003723	Molecular function	RNA binding

Gene name	MOV10L1
Protein name	RNA helicase (EC 3.6.4.13) MOV10L1 protein Mov10 like RISC complex RNA helicase 1 RNA helicase Mov10l1 (EC 3.6.4.13) (Moloney leukemia virus 10-like protein 1) (MOV10-like protein 1)
Synonyms
Description	FUNCTION: ATP-dependent RNA helicase required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Involved in the primary piRNA metabolic process. Specifically binds to piRNA precursors and promotes the generation of intermediate piRNA processing fragments that are subsequently loaded to Piwi proteins. Acts via its ATP-dependent RNA helicase activity: displays 5'-3' RNA unwinding activity and probably mediates unwinding and funneling of single-stranded piRNA precursor transcripts to the endonuclease that catalyzes the first cleavage step of piRNA processing to generate piRNA intermediate fragments that are subsequently loaded to Piwi proteins. .
Accessions	ENST00000262794.10 [Q9BXT6-1] ENST00000419054.5 Q9BXT6 F2Z2H1 ENST00000434497.1 ENST00000395852.5 [Q9BXT6-2] ENST00000354853.2 [Q9BXT6-3] B9EIS3 Q8IVP3 ENST00000395854.6 H7C1D5 ENST00000395858.7 [Q9BXT6-4] ENST00000540615.5 [Q9BXT6-5]

MOV10L1 report