MORC2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0045814Biological processnegative regulation of gene expression, epigenetic
GO_0045869Biological processnegative regulation of single stranded viral RNA replication via double stranded DNA intermediate
GO_0090309Biological processpositive regulation of DNA methylation-dependent heterochromatin formation
GO_0006974Biological processDNA damage response
GO_0006631Biological processfatty acid metabolic process
GO_0006338Biological processchromatin remodeling
GO_0000792Cellular componentheterochromatin
GO_0005654Cellular componentnucleoplasm
GO_0016363Cellular componentnuclear matrix
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0042803Molecular functionprotein homodimerization activity
GO_0003682Molecular functionchromatin binding
GO_0000287Molecular functionmagnesium ion binding
GO_0008270Molecular functionzinc ion binding
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding
GO_0016887Molecular functionATP hydrolysis activity

IV. Literature review

[source]
Gene nameMORC2
Protein nameMORC family CW-type zinc finger 2
ATPase MORC2 (EC 3.6.1.-) (MORC family CW-type zinc finger protein 2) (Zinc finger CW-type coiled-coil domain protein 1)
SynonymsKIAA0852
ZCWCC1
DescriptionFUNCTION: Essential for epigenetic silencing by the HUSH (human silencing hub) complex. Recruited by HUSH to target site in heterochromatin, the ATPase activity and homodimerization are critical for HUSH-mediated silencing . Represses germ cell-related genes and L1 retrotransposons in collaboration with SETDB1 and the HUSH complex, the silencing is dependent of repressive epigenetic modifications, such as H3K9me3 mark. Silencing events often occur within introns of transcriptionally active genes, and lead to the down-regulation of host gene expression . During DNA damage response, regulates chromatin remodeling through ATP hydrolysis. Upon DNA damage, is phosphorylated by PAK1, both colocalize to chromatin and induce H2AX expression. ATPase activity is required and dependent of phosphorylation by PAK1 and presence of DNA . Recruits histone deacetylases, such as HDAC4, to promoter regions, causing local histone H3 deacetylation and transcriptional repression of genes such as CA9 . Exhibits a cytosolic function in lipogenesis, adipogenic differentiation, and lipid homeostasis by increasing the activity of ACLY, possibly preventing its dephosphorylation . .

AccessionsQ9Y6X9
ENST00000215862.8 [Q9Y6X9-2]
H7C1V1
ENST00000397641.8 [Q9Y6X9-1]
ENST00000675779.1
A0A6Q8PGC6
ENST00000445980.5
A0A6Q8PHH3
ENST00000675570.1