MOGAT2 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of MOGAT2 at tissue level.

III. Associated gene sets

GO_0006071Biological processglycerol metabolic process
GO_0019432Biological processtriglyceride biosynthetic process
GO_0006640Biological processmonoacylglycerol biosynthetic process
GO_0050892Biological processintestinal absorption
GO_0006651Biological processdiacylglycerol biosynthetic process
GO_1990578Cellular componentperinuclear endoplasmic reticulum membrane
GO_0005783Cellular componentendoplasmic reticulum
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0016407Molecular functionacetyltransferase activity
GO_0003846Molecular function2-acylglycerol O-acyltransferase activity
GO_0004144Molecular functiondiacylglycerol O-acyltransferase activity

IV. Literature review

[source]
Gene nameMOGAT2
Protein name2-acylglycerol O-acyltransferase 2 (EC 2.3.1.20) (EC 2.3.1.22) (Acyl-CoA:monoacylglycerol acyltransferase 2) (MGAT2) (hMGAT2) (Diacylglycerol O-acyltransferase candidate 5) (hDC5) (Diacylglycerol acyltransferase 2-like protein 5) (Monoacylglycerol O-acyltransferase 2)
SynonymsDC5
DGAT2L5
DescriptionFUNCTION: Involved in glycerolipid synthesis and lipid metabolism . Catalyzes the formation of diacylglycerol, the precursor of triacylglycerol, by transferring the acyl chain of a fatty acyl-CoA to a monoacylglycerol . Plays a central role in absorption of dietary fat in the small intestine by catalyzing the resynthesis of triacylglycerol in enterocytes (By similarity). Has a preference toward monoacylglycerols containing unsaturated fatty acids in an order of C18:3 > C18:2 > C18:1 > C18:0 at sn-2 . Able to use 1-monoalkylglycerol (1-MAkG, 1-O-alkylglycerol) as an acyl acceptor for the synthesis of monoalkyl-monoacylglycerol (MAMAG, 1-O-alkyl-3-acylglycerol or 1-O-alkyl-2-acylglycerol) and subsequently, with lower efficiency, may add another acyl chain producing monoalkyl-diacylglycerol (MADAG, 1-O-alkyl-2,3-diacylglycerol) . Possesses weak but significant activity with diacylglycerol as substrate, producing triacylglycerol (triacyl-sn-glycerol) . .

AccessionsENST00000525093.5 [Q3SYC2-3]
Q3SYC2
ENST00000198801.10 [Q3SYC2-1]
ENST00000526712.1 [Q3SYC2-2]