MOCS3 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of MOCS3 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of MOCS3 at tissue level.

III. Associated gene sets

GO_0002098Biological processtRNA wobble uridine modification
GO_0034227Biological processtRNA thio-modification
GO_0006777Biological processMo-molybdopterin cofactor biosynthetic process
GO_0032447Biological processprotein urmylation
GO_0002143Biological processtRNA wobble position uridine thiolation
GO_0043545Biological processmolybdopterin cofactor metabolic process
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0016779Molecular functionnucleotidyltransferase activity
GO_0061605Molecular functionmolybdopterin-synthase adenylyltransferase activity
GO_0004792Molecular functionthiosulfate sulfurtransferase activity
GO_0016783Molecular functionsulfurtransferase activity
GO_0061604Molecular functionmolybdopterin-synthase sulfurtransferase activity
GO_0042292Molecular functionURM1 activating enzyme activity
GO_0005515Molecular functionprotein binding
GO_0046872Molecular functionmetal ion binding
GO_0005524Molecular functionATP binding

IV. Literature review

[source]
Gene nameMOCS3
Protein nameAdenylyltransferase and sulfurtransferase MOCS3 (Molybdenum cofactor synthesis protein 3) (Molybdopterin synthase sulfurylase) (MPT synthase sulfurylase) [Includes: Molybdopterin-synthase adenylyltransferase (EC 2.7.7.80) (Adenylyltransferase MOCS3) (Sulfur carrier protein MOCS2A adenylyltransferase); Molybdopterin-synthase sulfurtransferase (EC 2.8.1.11) (Sulfur carrier protein MOCS2A sulfurtransferase) (Sulfurtransferase MOCS3)]
SynonymsUBA4
DescriptionFUNCTION: Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A. Its N-terminus first activates URM1 and MOCS2A as acyl-adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (-COSH) of their C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as a nucleophile towards URM1 and MOCS2A. Subsequently, a transient disulfide bond is formed. Does not use thiosulfate as sulfur donor; NFS1 acting as a sulfur donor for thiocarboxylation reactions. .

AccessionsENST00000244051.3
O95396