MMP20 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of MMP20 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of MMP20 at tissue level.

III. Associated gene sets

GO_0030198Biological processextracellular matrix organization
GO_0022617Biological processextracellular matrix disassembly
GO_0030574Biological processcollagen catabolic process
GO_0006508Biological processproteolysis
GO_0097186Biological processamelogenesis
GO_0070173Biological processregulation of enamel mineralization
GO_0030163Biological processprotein catabolic process
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_0031012Cellular componentextracellular matrix
GO_0004222Molecular functionmetalloendopeptidase activity
GO_0005515Molecular functionprotein binding
GO_0008270Molecular functionzinc ion binding

IV. Literature review

[source]
Gene nameMMP20
Protein nameMetalloproteinase
Matrix metalloproteinase-20 (MMP-20) (EC 3.4.24.-) (Enamel metalloproteinase) (Enamelysin)
Synonymsmmp20
DescriptionFUNCTION: Degrades amelogenin, the major protein component of the enamel matrix and two of the macromolecules characterizing the cartilage extracellular matrix: aggrecan and the cartilage oligomeric matrix protein (COMP). May play a central role in tooth enamel formation. Cleaves aggrecan at the '360-Asn-|-Phe-361' site. .

AccessionsO43923
O60882
ENST00000260228.3