Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| macrophage | 12 studies | 29% ± 6% | |
| alveolar macrophage | 8 studies | 28% ± 9% | |
| fibroblast | 7 studies | 24% ± 8% | |
| myeloid cell | 5 studies | 24% ± 4% | |
| monocyte | 4 studies | 25% ± 7% | |
| adipocyte | 3 studies | 20% ± 3% |
Insufficient scRNA-seq data for expression of MMP19 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| lung | 100% | 6378.93 | 577 / 578 | 96% | 12.84 | 1105 / 1155 |
| breast | 100% | 4083.73 | 457 / 459 | 95% | 10.47 | 1060 / 1118 |
| bladder | 100% | 1634.38 | 21 / 21 | 91% | 11.04 | 459 / 504 |
| ovary | 97% | 3496.71 | 174 / 180 | 85% | 7.70 | 366 / 430 |
| uterus | 99% | 3477.39 | 168 / 170 | 78% | 7.93 | 356 / 459 |
| stomach | 89% | 2098.36 | 318 / 359 | 87% | 7.93 | 249 / 286 |
| intestine | 90% | 1710.95 | 870 / 966 | 84% | 7.39 | 441 / 527 |
| skin | 85% | 1835.83 | 1533 / 1809 | 74% | 4.66 | 347 / 472 |
| thymus | 89% | 1109.59 | 584 / 653 | 64% | 3.82 | 388 / 605 |
| esophagus | 60% | 684.63 | 873 / 1445 | 91% | 8.71 | 167 / 183 |
| prostate | 82% | 876.76 | 200 / 245 | 53% | 2.67 | 268 / 502 |
| pancreas | 26% | 233.63 | 84 / 328 | 97% | 21.41 | 172 / 178 |
| adrenal gland | 81% | 848.95 | 210 / 258 | 36% | 3.31 | 82 / 230 |
| kidney | 53% | 556.65 | 47 / 89 | 62% | 5.51 | 558 / 901 |
| adipose | 100% | 10205.64 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| spleen | 100% | 6811.58 | 241 / 241 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 100% | 6.21 | 1 / 1 |
| lymph node | 0% | 0 | 0 / 0 | 97% | 7.06 | 28 / 29 |
| tonsil | 0% | 0 | 0 / 0 | 93% | 12.95 | 42 / 45 |
| blood vessel | 90% | 2647.17 | 1199 / 1335 | 0% | 0 | 0 / 0 |
| liver | 19% | 250.25 | 44 / 226 | 56% | 3.20 | 226 / 406 |
| heart | 65% | 1074.35 | 560 / 861 | 0% | 0 | 0 / 0 |
| brain | 1% | 7.76 | 21 / 2642 | 32% | 3.89 | 226 / 705 |
| peripheral blood | 7% | 79.06 | 65 / 929 | 0% | 0 | 0 / 0 |
| muscle | 3% | 23.77 | 27 / 803 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 3% | 0.06 | 2 / 80 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0001525 | Biological process | angiogenesis |
| GO_0030198 | Biological process | extracellular matrix organization |
| GO_0022617 | Biological process | extracellular matrix disassembly |
| GO_0030574 | Biological process | collagen catabolic process |
| GO_0030154 | Biological process | cell differentiation |
| GO_0006508 | Biological process | proteolysis |
| GO_0005615 | Cellular component | extracellular space |
| GO_0005576 | Cellular component | extracellular region |
| GO_0031012 | Cellular component | extracellular matrix |
| GO_0004222 | Molecular function | metalloendopeptidase activity |
| GO_0004252 | Molecular function | serine-type endopeptidase activity |
| GO_0008270 | Molecular function | zinc ion binding |
| Gene name | MMP19 |
| Protein name | Matrix metalloproteinase-19 (MMP-19) (EC 3.4.24.-) (Matrix metalloproteinase RASI) (Matrix metalloproteinase-18) (MMP-18) Matrix metallopeptidase 19 Matrix metallopeptidase 19 (cDNA FLJ60740, moderately similar to Matrix metalloproteinase-19) |
| Synonyms | MMP18 RASI |
| Description | FUNCTION: Endopeptidase that degrades various components of the extracellular matrix, such as aggrecan and cartilage oligomeric matrix protein (comp), during development, haemostasis and pathological conditions (arthritic disease). May also play a role in neovascularization or angiogenesis. Hydrolyzes collagen type IV, laminin, nidogen, nascin-C isoform, fibronectin, and type I gelatin. . |
| Accessions | ENST00000552763.1 ENST00000322569.9 [Q99542-1] ENST00000409200.7 [Q99542-5] ENST00000548882.5 ENST00000552872.5 [Q99542-4] ENST00000548629.5 F8W1C3 B4DNP3 Q99542 A6ND33 |
