MMP13 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of MMP13 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of MMP13 at tissue level.

III. Associated gene sets

GO_0030198Biological processextracellular matrix organization
GO_0022617Biological processextracellular matrix disassembly
GO_0060349Biological processbone morphogenesis
GO_1904645Biological processresponse to amyloid-beta
GO_0003417Biological processgrowth plate cartilage development
GO_0030574Biological processcollagen catabolic process
GO_0001958Biological processendochondral ossification
GO_0006508Biological processproteolysis
GO_0030282Biological processbone mineralization
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_0031012Cellular componentextracellular matrix
GO_0004222Molecular functionmetalloendopeptidase activity
GO_0004175Molecular functionendopeptidase activity
GO_0005509Molecular functioncalcium ion binding
GO_0005518Molecular functioncollagen binding
GO_0004252Molecular functionserine-type endopeptidase activity
GO_0008270Molecular functionzinc ion binding

IV. Literature review

[source]
Gene nameMMP13
Protein nameCollagenase 3 (EC 3.4.24.-) (Matrix metalloproteinase-13) (MMP-13)
Alternative protein MMP13
Matrix metalloproteinase 13
Collagenase 3 (Matrix metalloproteinase-13)
SynonymshCG_39650
DescriptionFUNCTION: Plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN. Cleaves triple helical collagens, including type I, type II and type III collagen, but has the highest activity with soluble type II collagen. Can also degrade collagen type IV, type XIV and type X. May also function by activating or degrading key regulatory proteins, such as TGFB1 and CCN2. Plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization and ossification. Required for normal embryonic bone development and ossification. Plays a role in the healing of bone fractures via endochondral ossification. Plays a role in wound healing, probably by a mechanism that involves proteolytic activation of TGFB1 and degradation of CCN2. Plays a role in keratinocyte migration during wound healing. May play a role in cell migration and in tumor cell invasion. .

FUNCTION: Plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN. Cleaves triple helical collagens, including type I, type II and type III collagen, but has the highest activity with soluble type II collagen. Can also degrade collagen type IV, type XIV and type X. May also function by activating or degrading key regulatory proteins, such as TGFB1 and CCN2. Plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization and ossification. Required for normal embryonic bone development and ossification. Plays a role in the healing of bone fractures via endochondral ossification. Plays a role in wound healing, probably by a mechanism that involves proteolytic activation of TGFB1 and degradation of CCN2. Plays a role in keratinocyte migration during wound healing. May play a role in cell migration and in tumor cell invasion. .

AccessionsL8EA04
G5E971
L0R508
A0A4P8LAY1
P45452
ENST00000260302.8
ENST00000340273.4