MLLT1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0008023Cellular componenttranscription elongation factor complex
GO_0001650Cellular componentfibrillar center
GO_0070577Molecular functionlysine-acetylated histone binding
GO_0005515Molecular functionprotein binding
GO_0003682Molecular functionchromatin binding

IV. Literature review

[source]
Gene nameMLLT1
Protein nameProtein ENL (YEATS domain-containing protein 1)
SynonymsENL
LTG19
YEATS1
DescriptionFUNCTION: Chromatin reader component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA . Specifically recognizes and binds acetylated and crotonylated histones, with a preference for histones that are crotonylated . Has a slightly higher affinity for binding histone H3 crotonylated at 'Lys-27' (H3K27cr) than 'Lys-20' (H3K9cr20) . .; FUNCTION: Acts as a key chromatin reader in acute myeloid leukemia by recognizing and binding to acetylated histones via its YEATS domain, thereby regulating oncogenic gene transcription. .

AccessionsENST00000252674.9
Q03111