Name | Number of supported studies | Average coverage | |
---|---|---|---|
macrophage | 23 studies | 32% ± 14% | |
microglial cell | 14 studies | 46% ± 15% | |
myeloid cell | 10 studies | 32% ± 6% | |
classical monocyte | 6 studies | 23% ± 7% | |
GABAergic neuron | 6 studies | 35% ± 18% | |
glutamatergic neuron | 6 studies | 41% ± 22% | |
monocyte | 6 studies | 27% ± 10% | |
astrocyte | 6 studies | 28% ± 10% | |
non-classical monocyte | 5 studies | 20% ± 5% | |
endothelial cell | 5 studies | 21% ± 4% | |
epithelial cell | 4 studies | 29% ± 8% | |
dendritic cell | 4 studies | 24% ± 5% | |
leukocyte | 3 studies | 28% ± 14% | |
adipocyte | 3 studies | 20% ± 3% | |
mononuclear phagocyte | 3 studies | 35% ± 10% | |
tissue-resident macrophage | 3 studies | 27% ± 10% | |
fibroblast | 3 studies | 17% ± 2% | |
oligodendrocyte precursor cell | 3 studies | 26% ± 6% | |
alveolar macrophage | 3 studies | 35% ± 7% | |
interneuron | 3 studies | 37% ± 21% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
bladder | 100% | 2940.10 | 21 / 21 | 100% | 11.72 | 504 / 504 |
esophagus | 100% | 2933.75 | 1445 / 1445 | 100% | 12.61 | 183 / 183 |
intestine | 100% | 3739.68 | 966 / 966 | 100% | 9.35 | 527 / 527 |
lung | 100% | 4541.31 | 578 / 578 | 100% | 12.91 | 1155 / 1155 |
ovary | 100% | 2741.86 | 180 / 180 | 100% | 11.08 | 430 / 430 |
pancreas | 100% | 9902.79 | 328 / 328 | 100% | 10.91 | 178 / 178 |
prostate | 100% | 3069.46 | 245 / 245 | 100% | 7.52 | 502 / 502 |
skin | 100% | 1997.68 | 1809 / 1809 | 100% | 10.50 | 472 / 472 |
stomach | 100% | 2520.11 | 359 / 359 | 100% | 9.68 | 286 / 286 |
uterus | 100% | 2796.97 | 170 / 170 | 100% | 13.09 | 459 / 459 |
thymus | 100% | 2440.05 | 653 / 653 | 100% | 8.66 | 603 / 605 |
breast | 100% | 3034.89 | 459 / 459 | 100% | 10.20 | 1114 / 1118 |
kidney | 100% | 2270.52 | 89 / 89 | 99% | 9.14 | 896 / 901 |
liver | 100% | 1702.91 | 226 / 226 | 99% | 6.09 | 401 / 406 |
brain | 97% | 1848.96 | 2562 / 2642 | 99% | 10.94 | 700 / 705 |
adrenal gland | 100% | 2763.56 | 258 / 258 | 96% | 5.50 | 221 / 230 |
adipose | 100% | 3825.63 | 1204 / 1204 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 100% | 12.71 | 29 / 29 |
peripheral blood | 100% | 11812.39 | 929 / 929 | 0% | 0 | 0 / 0 |
spleen | 100% | 7508.26 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 13.37 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 2.95 | 1 / 1 |
blood vessel | 100% | 3064.88 | 1334 / 1335 | 0% | 0 | 0 / 0 |
muscle | 100% | 2140.21 | 802 / 803 | 0% | 0 | 0 / 0 |
heart | 99% | 2196.20 | 849 / 861 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 98% | 7.02 | 78 / 80 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0018105 | Biological process | peptidyl-serine phosphorylation |
GO_0035556 | Biological process | intracellular signal transduction |
GO_0006468 | Biological process | protein phosphorylation |
GO_0046777 | Biological process | protein autophosphorylation |
GO_0006417 | Biological process | regulation of translation |
GO_0005654 | Cellular component | nucleoplasm |
GO_0005829 | Cellular component | cytosol |
GO_0005737 | Cellular component | cytoplasm |
GO_0005634 | Cellular component | nucleus |
GO_0004683 | Molecular function | calmodulin-dependent protein kinase activity |
GO_0005516 | Molecular function | calmodulin binding |
GO_0009931 | Molecular function | calcium-dependent protein serine/threonine kinase activity |
GO_0004674 | Molecular function | protein serine/threonine kinase activity |
GO_0106310 | Molecular function | protein serine kinase activity |
GO_0005515 | Molecular function | protein binding |
GO_0046872 | Molecular function | metal ion binding |
GO_0005524 | Molecular function | ATP binding |
Gene name | MKNK1 |
Protein name | MAP kinase-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 1) (MAPK signal-integrating kinase 1) (Mnk1) non-specific serine/threonine protein kinase (EC 2.7.11.1) MAPK interacting serine/threonine kinase 1 MAP kinase-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 1) |
Synonyms | DKFZp686E14208 MNK1 |
Description | FUNCTION: May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap. . FUNCTION: May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap. . FUNCTION: May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap. . FUNCTION: May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap. . FUNCTION: May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap. . FUNCTION: May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap. . FUNCTION: May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap. . FUNCTION: May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap. . |
Accessions | ENST00000428112.7 E9PSE0 E9PII5 ENST00000496619.6 ENST00000371945.10 ENST00000650508.1 [Q9BUB5-2] ENST00000341183.9 ENST00000650026.1 [Q9BUB5-3] ENST00000531355.6 E9PN34 ENST00000524749.5 ENST00000532110.1 E9PMM8 ENST00000528077.6 A0A499FIS5 B5BUJ6 ENST00000465783.6 ENST00000531769.6 B5BU64 E9PIA0 Q9BUB5 ENST00000474868.2 ENST00000529170.6 E9PSC9 E9PLE7 ENST00000526513.6 E9PQ26 H0YE67 ENST00000371946.9 A0A499FJN1 ENST00000649800.1 [Q9BUB5-1] Q7Z319 A0A499FJS1 |