I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| epithelial cell | 3 studies | 22% ± 3% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| epithelial cell | 3 studies | 22% ± 3% |
Insufficient scRNA-seq data for expression of MIS12 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| esophagus | 100% | 1120.99 | 1445 / 1445 | 100% | 20.82 | 183 / 183 |
| ovary | 100% | 1228.97 | 180 / 180 | 100% | 18.54 | 430 / 430 |
| prostate | 100% | 1351.45 | 245 / 245 | 100% | 19.19 | 502 / 502 |
| breast | 100% | 1333.63 | 459 / 459 | 100% | 24.05 | 1117 / 1118 |
| lung | 100% | 1256.59 | 577 / 578 | 100% | 21.58 | 1155 / 1155 |
| brain | 100% | 862.51 | 2636 / 2642 | 100% | 29.91 | 705 / 705 |
| uterus | 100% | 1340.18 | 170 / 170 | 100% | 25.20 | 457 / 459 |
| thymus | 100% | 1643.59 | 653 / 653 | 100% | 21.70 | 602 / 605 |
| bladder | 100% | 1233.38 | 21 / 21 | 99% | 17.97 | 499 / 504 |
| stomach | 100% | 1091.12 | 359 / 359 | 99% | 16.30 | 283 / 286 |
| kidney | 100% | 1166.08 | 89 / 89 | 99% | 20.87 | 890 / 901 |
| adrenal gland | 100% | 1246.35 | 258 / 258 | 99% | 14.05 | 227 / 230 |
| intestine | 100% | 1369.15 | 966 / 966 | 99% | 17.35 | 520 / 527 |
| pancreas | 100% | 979.73 | 327 / 328 | 99% | 15.48 | 176 / 178 |
| skin | 100% | 1097.66 | 1809 / 1809 | 96% | 18.47 | 453 / 472 |
| liver | 100% | 998.58 | 226 / 226 | 94% | 10.32 | 380 / 406 |
| adipose | 100% | 1292.11 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 100% | 1035.16 | 1335 / 1335 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 25.60 | 29 / 29 |
| muscle | 100% | 949.59 | 803 / 803 | 0% | 0 | 0 / 0 |
| spleen | 100% | 2153.81 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 26.22 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 9.00 | 1 / 1 |
| heart | 99% | 734.98 | 854 / 861 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 85% | 11.05 | 68 / 80 |
| peripheral blood | 80% | 803.78 | 742 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0051315 | Biological process | attachment of mitotic spindle microtubules to kinetochore |
| GO_0008608 | Biological process | attachment of spindle microtubules to kinetochore |
| GO_0051301 | Biological process | cell division |
| GO_0051382 | Biological process | kinetochore assembly |
| GO_0007059 | Biological process | chromosome segregation |
| GO_0000070 | Biological process | mitotic sister chromatid segregation |
| GO_0000776 | Cellular component | kinetochore |
| GO_0005829 | Cellular component | cytosol |
| GO_0000922 | Cellular component | spindle pole |
| GO_0000444 | Cellular component | MIS12/MIND type complex |
| GO_0005634 | Cellular component | nucleus |
| GO_0005515 | Molecular function | protein binding |
| Gene name | MIS12 |
| Protein name | Protein MIS12 homolog MIS12 kinetochore complex component |
| Synonyms | |
| Description | FUNCTION: Part of the MIS12 complex which is required for normal chromosome alignment and segregation and for kinetochore formation during mitosis . Essential for proper kinetochore microtubule attachments . . |
| Accessions | ENST00000381165.3 ENST00000573759.1 Q9H081 ENST00000576988.1 I3L244 ENST00000576570.5 ENST00000611091.5 I3L4K6 |
