MIOS report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0034198Biological processcellular response to amino acid starvation
GO_0031669Biological processcellular response to nutrient levels
GO_0032289Biological processcentral nervous system myelin formation
GO_1904263Biological processpositive regulation of TORC1 signaling
GO_0048709Biological processoligodendrocyte differentiation
GO_0070444Biological processoligodendrocyte progenitor proliferation
GO_1904262Biological processnegative regulation of TORC1 signaling
GO_0031503Biological processprotein-containing complex localization
GO_0030054Cellular componentcell junction
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0061700Cellular componentGATOR2 complex
GO_0005765Cellular componentlysosomal membrane
GO_0005737Cellular componentcytoplasm
GO_0005515Molecular functionprotein binding
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameMIOS
Protein nameMeiosis regulator for oocyte development
GATOR2 complex protein MIOS (Missing oocyte meiosis regulator homolog)
Synonyms
DescriptionFUNCTION: As a component of the GATOR2 complex, functions as an activator of the amino acid-sensing branch of the mTORC1 signaling pathway . The GATOR2 complex indirectly activates mTORC1 through the inhibition of the GATOR1 subcomplex . GATOR2 probably acts as an E3 ubiquitin-protein ligase toward GATOR1 . In the presence of abundant amino acids, the GATOR2 complex mediates ubiquitination of the NPRL2 core component of the GATOR1 complex, leading to GATOR1 inactivation . In the absence of amino acids, GATOR2 is inhibited, activating the GATOR1 complex . Within the GATOR2 complex, MIOS is required to prevent autoubiquitination of WDR24, the catalytic subunit of the complex . The GATOR2 complex is required for brain myelination (By similarity). .

AccessionsENST00000405785.5 [Q9NXC5-1]
ENST00000340080.9 [Q9NXC5-1]
ENST00000433635.1
Q9NXC5
C9JUE6
C9JAQ1
ENST00000445169.1
ENST00000433056.5
C9JTV2
ENST00000456533.1