MINPP1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0043647Biological processinositol phosphate metabolic process
GO_0030282Biological processbone mineralization
GO_0030003Biological processintracellular monoatomic cation homeostasis
GO_0001503Biological processossification
GO_0005615Cellular componentextracellular space
GO_0005886Cellular componentplasma membrane
GO_0070062Cellular componentextracellular exosome
GO_0005788Cellular componentendoplasmic reticulum lumen
GO_0030351Molecular functioninositol-1,3,4,5,6-pentakisphosphate 3-phosphatase activity
GO_0016158Molecular function3-phytase activity
GO_0051717Molecular functioninositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity
GO_0003993Molecular functionacid phosphatase activity
GO_0034417Molecular functionbisphosphoglycerate 3-phosphatase activity
GO_0016312Molecular functioninositol bisphosphate phosphatase activity
GO_0008707Molecular function4-phytase activity
GO_0046030Molecular functioninositol trisphosphate phosphatase activity
GO_0052826Molecular functioninositol hexakisphosphate 2-phosphatase activity
GO_0052827Molecular functioninositol pentakisphosphate phosphatase activity
GO_0030352Molecular functioninositol-1,4,5,6-tetrakisphosphate 6-phosphatase activity
GO_0052745Molecular functioninositol phosphate phosphatase activity
GO_0004446Molecular functioninositol-hexakisphosphate phosphatase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameMINPP1
Protein nameMultiple inositol polyphosphate phosphatase 1 (EC 3.1.3.62) (2,3-bisphosphoglycerate 3-phosphatase) (2,3-BPG phosphatase) (EC 3.1.3.80)
SynonymsMIPP
UNQ900/PRO1917
DescriptionFUNCTION: Multiple inositol polyphosphate phosphatase that hydrolyzes 1D-myo-inositol 1,3,4,5,6-pentakisphosphate (InsP5[2OH]) and 1D-myo-inositol hexakisphosphate (InsP6) to a range of less phosphorylated inositol phosphates. This regulates the availability of these various small molecule second messengers and metal chelators which control many aspects of cell physiology . Has a weak in vitro activity towards 1D-myo-inositol 1,4,5-trisphosphate which is unlikely to be physiologically relevant . By regulating intracellular inositol polyphosphates pools, which act as metal chelators, it may control the availability of intracellular calcium and iron, which are important for proper neuronal development and homeostasis . May have a dual substrate specificity, and function as a 2,3-bisphosphoglycerate 3-phosphatase hydrolyzing 2,3-bisphosphoglycerate to 2-phosphoglycerate. 2,3-bisphosphoglycerate (BPG) is formed as part of the Rapoport-Luebering glycolytic bypass and is a regulator of systemic oxygen homeostasis as the major allosteric effector of hemoglobin . .

AccessionsENST00000371994.8 [Q9UNW1-2]
Q9UNW1
ENST00000536010.1 [Q9UNW1-4]
ENST00000371996.9 [Q9UNW1-1]