MIEF1 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of MIEF1 at tissue level.

III. Associated gene sets

GO_0070131Biological processpositive regulation of mitochondrial translation
GO_0000266Biological processmitochondrial fission
GO_0090141Biological processpositive regulation of mitochondrial fission
GO_0008053Biological processmitochondrial fusion
GO_0090314Biological processpositive regulation of protein targeting to membrane
GO_1902775Biological processmitochondrial large ribosomal subunit assembly
GO_0010636Biological processpositive regulation of mitochondrial fusion
GO_0071456Biological processcellular response to hypoxia
GO_0032981Biological processmitochondrial respiratory chain complex I assembly
GO_0005741Cellular componentmitochondrial outer membrane
GO_0005777Cellular componentperoxisome
GO_0005759Cellular componentmitochondrial matrix
GO_0005739Cellular componentmitochondrion
GO_0019003Molecular functionGDP binding
GO_0140978Molecular functionmitochondrial large ribosomal subunit binding
GO_0043531Molecular functionADP binding
GO_0042802Molecular functionidentical protein binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameMIEF1
Protein nameMitochondrial ribosome and complex I assembly factor AltMIEF1 (Alternative MIEF1 protein) (AltMIEF1) (MIEF1 microprotein) (MIEF1-MP) (alternative transcript upstream of MiD51) (AltMiD51)
Mitochondrial dynamics protein MIEF1 (Mitochondrial dynamics protein of 51 kDa) (Mitochondrial elongation factor 1) (Smith-Magenis syndrome chromosomal region candidate gene 7 protein-like) (SMCR7-like protein)
Mitochondrial elongation factor 1 (Smith-Magenis syndrome chromosomal region candidate gene 7 protein-like)
Mitochondrial elongation factor 1
SynonymshCG_41725
RP5-1104E15.5
AltMIEF1
SMCR7L
AltMiD51
MID51
DescriptionFUNCTION: Assembly factor involved in the biogenesis of the mitochondrial-specific ribosomes (mitoribosomes) . Specifically associates with intermediates of the mitochondrial ribosome large subunit (mt-LSU) and is required for proper ribosome assembly, possibly preventing premature association of the large and small ribosomal subunits . Thereby, indirectly regulates mitochondrial translation . It is also required for complete assembly of the mitochondrial respiratory chain complex I . May also function in DNM1L-mediated mitochondrial fission . .

FUNCTION: Mitochondrial outer membrane protein which regulates mitochondrial fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface independently of the mitochondrial fission FIS1 and MFF proteins. Regulates DNM1L GTPase activity and DNM1L oligomerization. Binds ADP and can also bind GDP, although with lower affinity. Does not bind CDP, UDP, ATP, AMP or GTP. Inhibits DNM1L GTPase activity in the absence of bound ADP. Requires ADP to stimulate DNM1L GTPase activity and the assembly of DNM1L into long, oligomeric tubules with a spiral pattern, as opposed to the ring-like DNM1L oligomers observed in the absence of bound ADP. Does not require ADP for its function in recruiting DNM1L. .

AccessionsENST00000433117.6 [Q9NQG6-2]
ENST00000404569.5 [Q9NQG6-1]
ENST00000434364.5
ENST00000428069.1 [Q9NQG6-2]
B0QY94
ENST00000325301.7 [Q9NQG6-1]
L0R8F8
Q9NQG6
B0QY95
ENST00000402881.5