MGME1 | OmnibusX

Name	Number of supported studies	Average coverage
epithelial cell	5 studies	26% ± 8%	Explore
basal cell	3 studies	24% ± 8%	Explore

Name	Number of supported studies	Average coverage
liver	3 studies	28% ± 7%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
breast	100%	1134.35	459 / 459	100%	52.40	1118 / 1118
bladder	100%	740.62	21 / 21	100%	47.80	503 / 504
esophagus	100%	833.99	1441 / 1445	100%	45.20	183 / 183
intestine	100%	869.07	966 / 966	100%	42.27	525 / 527
skin	100%	2256.82	1809 / 1809	100%	66.14	470 / 472
thymus	100%	1219.74	653 / 653	99%	36.18	601 / 605
ovary	99%	518.33	179 / 180	100%	41.97	429 / 430
prostate	100%	858.44	245 / 245	99%	24.58	498 / 502
uterus	99%	534.35	169 / 170	100%	62.75	458 / 459
stomach	99%	600.10	356 / 359	100%	41.17	286 / 286
lung	99%	685.86	573 / 578	100%	45.13	1154 / 1155
kidney	100%	915.42	89 / 89	99%	28.13	888 / 901
pancreas	98%	508.57	323 / 328	99%	26.54	176 / 178
brain	96%	408.15	2547 / 2642	99%	27.40	699 / 705
adrenal gland	100%	1369.93	258 / 258	95%	24.28	219 / 230
liver	100%	594.22	226 / 226	94%	22.42	383 / 406
lymph node	0%	0	0 / 0	100%	62.00	29 / 29
spleen	100%	1808.80	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	66.20	45 / 45
ureter	0%	0	0 / 0	100%	26.19	1 / 1
muscle	100%	904.23	801 / 803	0%	0	0 / 0
adipose	100%	686.11	1201 / 1204	0%	0	0 / 0
blood vessel	99%	646.55	1323 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	99%	50.37	79 / 80
heart	95%	593.93	818 / 861	0%	0	0 / 0
peripheral blood	94%	937.94	873 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

GO_0043504	Biological process	mitochondrial DNA repair
GO_0006264	Biological process	mitochondrial DNA replication
GO_0000002	Biological process	mitochondrial genome maintenance
GO_0005739	Cellular component	mitochondrion
GO_0005515	Molecular function	protein binding
GO_0045145	Molecular function	single-stranded DNA 5'-3' DNA exonuclease activity
GO_0008297	Molecular function	single-stranded DNA exodeoxyribonuclease activity

Gene name	MGME1
Protein name	Mitochondrial genome maintenance exonuclease 1 (EC 3.1.-.-) Mitochondrial genome maintenance exonuclease 1
Synonyms	C20orf72 DDK1
Description	FUNCTION: Metal-dependent single-stranded DNA (ssDNA) exonuclease involved in mitochondrial genome maintenance. Has preference for 5'-3' exonuclease activity but is also capable of endoduclease activity on linear substrates. Necessary for maintenance of proper 7S DNA levels. Probably involved in mitochondrial DNA (mtDNA) repair, possibly via the processing of displaced DNA containing Okazaki fragments during RNA-primed DNA synthesis on the lagging strand or via processing of DNA flaps during long-patch base excision repair. Specifically binds 5-hydroxymethylcytosine (5hmC)-containing DNA in stem cells. . FUNCTION: Metal-dependent single-stranded DNA (ssDNA) exonuclease involved in mitochondrial genome maintenance. Has preference for 5'-3' exonuclease activity but is also capable of endoduclease activity on linear substrates. Necessary for maintenance of proper 7S DNA levels. Probably involved in mitochondrial DNA (mtDNA) repair, possibly via the processing of displaced DNA containing Okazaki fragments during RNA-primed DNA synthesis on the lagging strand or via processing of DNA flaps during long-patch base excision repair. .
Accessions	Q5QPE8 ENST00000377704.4 ENST00000377709.1 Q5QPE7 ENST00000377710.10 Q9BQP7

MGME1 report