MFN1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0046039Biological processGTP metabolic process
GO_0008053Biological processmitochondrial fusion
GO_0010918Biological processpositive regulation of mitochondrial membrane potential
GO_0051646Biological processmitochondrion localization
GO_0005741Cellular componentmitochondrial outer membrane
GO_0005739Cellular componentmitochondrion
GO_0016020Cellular componentmembrane
GO_0098799Cellular componentouter mitochondrial membrane protein complex
GO_0005525Molecular functionGTP binding
GO_0042802Molecular functionidentical protein binding
GO_0005515Molecular functionprotein binding
GO_0003924Molecular functionGTPase activity

IV. Literature review

[source]
Gene nameMFN1
Protein nameMitofusin 1
MFN1 protein
Mitofusin-1 (EC 3.6.5.-) (Fzo homolog) (Transmembrane GTPase MFN1)
Synonyms
DescriptionFUNCTION: Mitochondrial outer membrane GTPase that mediates mitochondrial clustering and fusion . Membrane clustering requires GTPase activity . It may involve a major rearrangement of the coiled coil domains . Mitochondria are highly dynamic organelles, and their morphology is determined by the equilibrium between mitochondrial fusion and fission events . Overexpression induces the formation of mitochondrial networks (in vitro) . Has low GTPase activity . .

AccessionsH7C5H5
C9JXQ1
ENST00000489329.5
ENST00000467174.6
Q8IWA4
ENST00000357390.8 [Q8IWA4-2]
Q05CV7
C9JQT7
ENST00000471841.6 [Q8IWA4-1]
ENST00000263969.9 [Q8IWA4-1]
ENST00000474903.1