Name | Number of supported studies | Average coverage | |
---|---|---|---|
oligodendrocyte | 5 studies | 17% ± 1% | |
epithelial cell | 3 studies | 18% ± 1% | |
GABAergic neuron | 3 studies | 30% ± 4% | |
glutamatergic neuron | 3 studies | 33% ± 6% | |
oligodendrocyte precursor cell | 3 studies | 21% ± 3% |
Name | Number of supported studies | Average coverage | |
---|---|---|---|
brain | 5 studies | 23% ± 5% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 549.85 | 1445 / 1445 | 100% | 9.75 | 183 / 183 |
brain | 100% | 489.78 | 2635 / 2642 | 100% | 7.61 | 705 / 705 |
lung | 100% | 527.97 | 577 / 578 | 100% | 7.77 | 1150 / 1155 |
breast | 100% | 653.10 | 459 / 459 | 99% | 8.16 | 1111 / 1118 |
uterus | 100% | 901.43 | 170 / 170 | 99% | 9.27 | 455 / 459 |
prostate | 100% | 768.62 | 245 / 245 | 99% | 6.02 | 496 / 502 |
thymus | 100% | 798.39 | 653 / 653 | 99% | 7.05 | 597 / 605 |
ovary | 100% | 746.63 | 180 / 180 | 98% | 6.38 | 421 / 430 |
bladder | 100% | 705.90 | 21 / 21 | 97% | 7.48 | 490 / 504 |
stomach | 100% | 474.19 | 359 / 359 | 97% | 6.02 | 278 / 286 |
pancreas | 98% | 260.74 | 323 / 328 | 98% | 6.75 | 175 / 178 |
intestine | 100% | 665.46 | 966 / 966 | 96% | 5.93 | 508 / 527 |
kidney | 100% | 538.22 | 89 / 89 | 94% | 5.84 | 848 / 901 |
skin | 100% | 579.33 | 1808 / 1809 | 92% | 6.76 | 436 / 472 |
adrenal gland | 100% | 457.21 | 257 / 258 | 90% | 5.60 | 206 / 230 |
liver | 100% | 274.20 | 226 / 226 | 64% | 2.68 | 261 / 406 |
lymph node | 0% | 0 | 0 / 0 | 100% | 7.74 | 29 / 29 |
spleen | 100% | 1103.12 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 11.12 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 3.62 | 1 / 1 |
adipose | 100% | 695.29 | 1203 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 498.17 | 1333 / 1335 | 0% | 0 | 0 / 0 |
heart | 99% | 375.90 | 851 / 861 | 0% | 0 | 0 / 0 |
muscle | 97% | 235.19 | 777 / 803 | 0% | 0 | 0 / 0 |
peripheral blood | 93% | 481.48 | 862 / 929 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 60% | 2.80 | 48 / 80 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0045814 | Biological process | negative regulation of gene expression, epigenetic |
GO_0043484 | Biological process | regulation of RNA splicing |
GO_0090296 | Biological process | regulation of mitochondrial DNA replication |
GO_0032259 | Biological process | methylation |
GO_1903108 | Biological process | regulation of mitochondrial transcription |
GO_0016556 | Biological process | mRNA modification |
GO_0120049 | Biological process | snRNA (adenine-N6)-methylation |
GO_0005829 | Cellular component | cytosol |
GO_0036396 | Cellular component | RNA N6-methyladenosine methyltransferase complex |
GO_0005759 | Cellular component | mitochondrial matrix |
GO_0005634 | Cellular component | nucleus |
GO_0008173 | Molecular function | RNA methyltransferase activity |
GO_0009007 | Molecular function | site-specific DNA-methyltransferase (adenine-specific) activity |
GO_0106347 | Molecular function | U2 snRNA 2'-O-methyladenosine m6 methyltransferase activity |
GO_0003676 | Molecular function | nucleic acid binding |
Gene name | METTL4 |
Protein name | METTL4 protein Alternative protein METTL4 N(6)-adenine-specific methyltransferase METTL4 (Methyltransferase-like protein 4) (N(6)-adenine-specific DNA methyltransferase METTL4) (EC 2.1.1.72) (snRNA (2'-O-methyladenosine-N(6)-)-methyltransferase METTL4) (EC 2.1.1.-) Methyltransferase 4, N6-adenosine |
Synonyms | |
Description | FUNCTION: N(6)-adenine-specific methyltransferase that can methylate both RNAs and DNA . Acts as a N(6)-adenine-specific RNA methyltransferase by catalyzing formation of N6,2'-O-dimethyladenosine (m6A(m)) on internal positions of U2 small nuclear RNA (snRNA): methylates the 6th position of adenine residues with a pre-deposited 2'-O-methylation . Internal m6A(m) methylation of snRNAs regulates RNA splicing . Also able to act as a N(6)-adenine-specific DNA methyltransferase by mediating methylation of DNA on the 6th position of adenine (N(6)-methyladenosine) . The existence of N(6)-methyladenosine (m6A) on DNA is however unclear in mammals, and additional evidences are required to confirm the role of the N(6)-adenine-specific DNA methyltransferase activity of METTL4 in vivo . Acts as a regulator of mitochondrial transcript levels and mitochondrial DNA (mtDNA) copy number by mediating mtDNA N(6)-methylation: m6A on mtDNA reduces transcription by repressing TFAM DNA-binding and bending . N(6)-methyladenosine deposition by METTL4 regulates Polycomb silencing by triggering ubiquitination and degradation of sensor proteins ASXL1 and MPND, leading to inactivation of the PR-DUB complex and subsequent preservation of Polycomb silencing (By similarity). . |
Accessions | ENST00000609769.1 I3L3W2 ENST00000576251.5 ENST00000577166.5 Q8N3J2 ENST00000319888.10 ENST00000574538.2 V9GYU3 ENST00000574676.1 I3L0Y1 J3KNJ7 I6L9E3 L8EB52 I3L4A0 |