METTL4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0045814Biological processnegative regulation of gene expression, epigenetic
GO_0043484Biological processregulation of RNA splicing
GO_0090296Biological processregulation of mitochondrial DNA replication
GO_0032259Biological processmethylation
GO_1903108Biological processregulation of mitochondrial transcription
GO_0016556Biological processmRNA modification
GO_0120049Biological processsnRNA (adenine-N6)-methylation
GO_0005829Cellular componentcytosol
GO_0036396Cellular componentRNA N6-methyladenosine methyltransferase complex
GO_0005759Cellular componentmitochondrial matrix
GO_0005634Cellular componentnucleus
GO_0008173Molecular functionRNA methyltransferase activity
GO_0009007Molecular functionsite-specific DNA-methyltransferase (adenine-specific) activity
GO_0106347Molecular functionU2 snRNA 2'-O-methyladenosine m6 methyltransferase activity
GO_0003676Molecular functionnucleic acid binding

IV. Literature review

[source]
Gene nameMETTL4
Protein nameMETTL4 protein
Alternative protein METTL4
N(6)-adenine-specific methyltransferase METTL4 (Methyltransferase-like protein 4) (N(6)-adenine-specific DNA methyltransferase METTL4) (EC 2.1.1.72) (snRNA (2'-O-methyladenosine-N(6)-)-methyltransferase METTL4) (EC 2.1.1.-)
Methyltransferase 4, N6-adenosine
Synonyms
DescriptionFUNCTION: N(6)-adenine-specific methyltransferase that can methylate both RNAs and DNA . Acts as a N(6)-adenine-specific RNA methyltransferase by catalyzing formation of N6,2'-O-dimethyladenosine (m6A(m)) on internal positions of U2 small nuclear RNA (snRNA): methylates the 6th position of adenine residues with a pre-deposited 2'-O-methylation . Internal m6A(m) methylation of snRNAs regulates RNA splicing . Also able to act as a N(6)-adenine-specific DNA methyltransferase by mediating methylation of DNA on the 6th position of adenine (N(6)-methyladenosine) . The existence of N(6)-methyladenosine (m6A) on DNA is however unclear in mammals, and additional evidences are required to confirm the role of the N(6)-adenine-specific DNA methyltransferase activity of METTL4 in vivo . Acts as a regulator of mitochondrial transcript levels and mitochondrial DNA (mtDNA) copy number by mediating mtDNA N(6)-methylation: m6A on mtDNA reduces transcription by repressing TFAM DNA-binding and bending . N(6)-methyladenosine deposition by METTL4 regulates Polycomb silencing by triggering ubiquitination and degradation of sensor proteins ASXL1 and MPND, leading to inactivation of the PR-DUB complex and subsequent preservation of Polycomb silencing (By similarity). .

AccessionsENST00000609769.1
I3L3W2
ENST00000576251.5
ENST00000577166.5
Q8N3J2
ENST00000319888.10
ENST00000574538.2
V9GYU3
ENST00000574676.1
I3L0Y1
J3KNJ7
I6L9E3
L8EB52
I3L4A0