METTL18 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of METTL18 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of METTL18 at tissue level.

III. Associated gene sets

GO_0090069Biological processregulation of ribosome biogenesis
GO_0018022Biological processpeptidyl-lysine methylation
GO_2000232Biological processregulation of rRNA processing
GO_0042038Biological processpeptidyl-histidine methylation, to form tele-methylhistidine
GO_0018026Biological processpeptidyl-lysine monomethylation
GO_0006448Biological processregulation of translational elongation
GO_0006417Biological processregulation of translation
GO_0005730Cellular componentnucleolus
GO_0032991Cellular componentprotein-containing complex
GO_0005829Cellular componentcytosol
GO_0005634Cellular componentnucleus
GO_0031072Molecular functionheat shock protein binding
GO_0005515Molecular functionprotein binding
GO_0016279Molecular functionprotein-lysine N-methyltransferase activity
GO_0018064Molecular functionprotein-L-histidine N-tele-methyltransferase activity

IV. Literature review

[source]
Gene nameMETTL18
Protein nameMethyltransferase like 18
Histidine protein methyltransferase 1 homolog (EC 2.1.1.85) (Arsenic-transactivated protein 2) (AsTP2) (Methyltransferase-like protein 18)
SynonymsC1orf156
ASTP2
DescriptionFUNCTION: Protein-L-histidine N-tele-methyltransferase that specifically monomethylates RPL3, thereby regulating translation elongation . Histidine methylation of RPL3 regulates translation elongation by slowing ribosome traversal on tyrosine codons: slower elongation provides enough time for proper folding of synthesized proteins and prevents cellular aggregation of tyrosine-rich proteins . .

AccessionsO95568
ENST00000310392.5
ENST00000303469.6
Q5TI78
ENST00000454472.1