METTL1 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of METTL1 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of METTL1 at tissue level.

III. Associated gene sets

GO_0036416Biological processtRNA stabilization
GO_0030488Biological processtRNA methylation
GO_0036265Biological processRNA (guanine-N7)-methylation
GO_0106004Biological processtRNA (guanine-N7)-methylation
GO_0006400Biological processtRNA modification
GO_0043527Cellular componenttRNA methyltransferase complex
GO_0005730Cellular componentnucleolus
GO_0106143Cellular componenttRNA (m7G46) methyltransferase complex
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005634Cellular componentnucleus
GO_0000049Molecular functiontRNA binding
GO_0008176Molecular functiontRNA (guanine(46)-N7)-methyltransferase activity
GO_0005515Molecular functionprotein binding
GO_0160090Molecular functioninternal mRNA (guanine-N7-)-methyltransferase activity

IV. Literature review

[source]
Gene nameMETTL1
Protein nametRNA (guanine-N(7)-)-methyltransferase (EC 2.1.1.33) (Methyltransferase-like protein 1) (mRNA (guanine-N(7)-)-methyltransferase) (EC 2.1.1.-) (miRNA (guanine-N(7)-)-methyltransferase) (EC 2.1.1.-) (tRNA (guanine(46)-N(7))-methyltransferase) (tRNA(m7G46)-methyltransferase)
Methyltransferase 1, tRNA methylguanosine
SynonymsC12orf1
DescriptionFUNCTION: Catalytic component of METTL1-WDR4 methyltransferase complex that mediates the formation of N(7)-methylguanine in a subset of RNA species, such as tRNAs, mRNAs and microRNAs (miRNAs) . Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in a large subset of tRNAs that contain the 5'-RAGGU-3' motif within the variable loop . M7G46 interacts with C13-G22 in the D-loop to stabilize tRNA tertiary structure and protect tRNAs from decay . Also acts as a methyltransferase for a subset of internal N(7)-methylguanine in mRNAs . Internal N(7)-methylguanine methylation of mRNAs in response to stress promotes their relocalization to stress granules, thereby suppressing their translation . Also methylates a specific subset of miRNAs, such as let-7 . N(7)-methylguanine methylation of let-7 miRNA promotes let-7 miRNA processing by disrupting an inhibitory secondary structure within the primary miRNA transcript (pri-miRNA) . Acts as a regulator of embryonic stem cell self-renewal and differentiation (By similarity). .

AccessionsENST00000553125.5
H0YHX0
ENST00000324871.12 [Q9UBP6-1]
ENST00000257848.7 [Q9UBP6-2]
ENST00000547653.1
H0YIH0
Q9UBP6
H0YHU4
ENST00000551117.1
ENST00000548504.1
F8VSD9