MEIOB report

I. Expression across cell types

Insufficient scRNA-seq data for expression of MEIOB at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of MEIOB at tissue level.

III. Associated gene sets

GO_0007140Biological processmale meiotic nuclear division
GO_0000724Biological processdouble-strand break repair via homologous recombination
GO_0007144Biological processfemale meiosis I
GO_0009566Biological processfertilization
GO_0007129Biological processhomologous chromosome pairing at meiosis
GO_0007141Biological processmale meiosis I
GO_0000712Biological processresolution of meiotic recombination intermediates
GO_0005694Cellular componentchromosome
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0008310Molecular functionsingle-stranded DNA 3'-5' DNA exonuclease activity
GO_0003697Molecular functionsingle-stranded DNA binding
GO_0003682Molecular functionchromatin binding

IV. Literature review

[source]
Gene nameMEIOB
Protein nameMeiosis-specific with OB domain-containing protein (EC 3.1.-.-)
Meiosis specific with OB-fold
SynonymsC16orf73
DescriptionFUNCTION: Single-stranded DNA-binding protein required for homologous recombination in meiosis I. Required for double strand breaks (DSBs) repair and crossover formation and promotion of faithful and complete synapsis. Not required for the initial loading of recombinases but required to maintain a proper number of RAD51 and DMC1 foci after the zygotene stage. May act by ensuring the stabilization of recombinases, which is required for successful homology search and meiotic recombination. Displays Single-stranded DNA 3'-5' exonuclease activity in vitro. .

AccessionsQ8N635
ENST00000496541.6
H3BU18
ENST00000460494.3
H3BSU6
ENST00000325962.9 [Q8N635-2]
ENST00000397344.7 [Q8N635-1]