I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| retinal rod cell | 4 studies | 22% ± 3% | |
| glutamatergic neuron | 4 studies | 36% ± 18% | |
| epithelial cell | 3 studies | 29% ± 9% | |
| astrocyte | 3 studies | 17% ± 2% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| retinal rod cell | 4 studies | 22% ± 3% | |
| glutamatergic neuron | 4 studies | 36% ± 18% | |
| epithelial cell | 3 studies | 29% ± 9% | |
| astrocyte | 3 studies | 17% ± 2% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| brain | 5 studies | 25% ± 12% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| esophagus | 100% | 936.40 | 1445 / 1445 | 100% | 10.76 | 183 / 183 |
| liver | 100% | 825.24 | 226 / 226 | 100% | 12.77 | 406 / 406 |
| ovary | 100% | 1112.83 | 180 / 180 | 100% | 19.06 | 430 / 430 |
| prostate | 100% | 981.27 | 245 / 245 | 100% | 15.89 | 502 / 502 |
| skin | 100% | 1421.81 | 1809 / 1809 | 100% | 21.98 | 472 / 472 |
| stomach | 100% | 786.53 | 359 / 359 | 100% | 13.01 | 286 / 286 |
| uterus | 100% | 1242.98 | 170 / 170 | 100% | 18.76 | 459 / 459 |
| brain | 100% | 1393.94 | 2640 / 2642 | 100% | 19.98 | 705 / 705 |
| breast | 100% | 1372.08 | 459 / 459 | 100% | 17.56 | 1117 / 1118 |
| kidney | 100% | 1140.12 | 89 / 89 | 100% | 14.29 | 900 / 901 |
| thymus | 100% | 984.02 | 653 / 653 | 100% | 16.42 | 604 / 605 |
| intestine | 100% | 892.56 | 966 / 966 | 100% | 14.67 | 526 / 527 |
| pancreas | 100% | 572.59 | 327 / 328 | 100% | 13.95 | 178 / 178 |
| bladder | 100% | 987.62 | 21 / 21 | 100% | 17.57 | 502 / 504 |
| adrenal gland | 100% | 1244.48 | 258 / 258 | 99% | 12.66 | 227 / 230 |
| lung | 99% | 741.85 | 570 / 578 | 100% | 14.33 | 1155 / 1155 |
| adipose | 100% | 1380.68 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 100% | 24.79 | 80 / 80 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 14.98 | 29 / 29 |
| muscle | 100% | 1756.74 | 803 / 803 | 0% | 0 | 0 / 0 |
| spleen | 100% | 703.66 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 16.28 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 15.19 | 1 / 1 |
| blood vessel | 100% | 861.54 | 1331 / 1335 | 0% | 0 | 0 / 0 |
| heart | 98% | 1191.61 | 842 / 861 | 0% | 0 | 0 / 0 |
| peripheral blood | 43% | 359.13 | 402 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0006633 | Biological process | fatty acid biosynthetic process |
| GO_0006631 | Biological process | fatty acid metabolic process |
| GO_0005759 | Cellular component | mitochondrial matrix |
| GO_0005739 | Cellular component | mitochondrion |
| GO_0005634 | Cellular component | nucleus |
| GO_0141148 | Molecular function | enoyl-[acyl-carrier-protein] reductase (NADPH) activity |
| Gene name | MECR |
| Protein name | Enoyl-[acyl-carrier-protein] reductase, mitochondrial (EC 1.3.1.104) (2-enoyl thioester reductase) (Nuclear receptor-binding factor 1) (HsNrbf-1) (NRBF-1) Mitochondrial trans-2-enoyl-CoA reductase |
| Synonyms | CGI-63 NBRF1 |
| Description | FUNCTION: Catalyzes the NADPH-dependent reduction of trans-2-enoyl thioesters in mitochondrial fatty acid synthesis (fatty acid synthesis type II). Fatty acid chain elongation in mitochondria uses acyl carrier protein (ACP) as an acyl group carrier, but the enzyme accepts both ACP and CoA thioesters as substrates in vitro. Displays a preference for medium-chain over short- and long-chain substrates . May provide the octanoyl chain used for lipoic acid biosynthesis, regulating protein lipoylation and mitochondrial respiratory activity particularly in Purkinje cells (By similarity). . |
| Accessions | H3BM30 Q9BV79 ENST00000373791.7 [Q9BV79-2] ENST00000263702.11 [Q9BV79-1] ENST00000463412.1 |
