MCIDAS report

I. Expression across cell types

Insufficient scRNA-seq data for expression of MCIDAS at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of MCIDAS at tissue level.

III. Associated gene sets

GO_0060271Biological processcilium assembly
GO_1903251Biological processmulti-ciliated epithelial cell differentiation
GO_0008156Biological processnegative regulation of DNA replication
GO_0045786Biological processnegative regulation of cell cycle
GO_0098534Biological processcentriole assembly
GO_1902017Biological processregulation of cilium assembly
GO_0007346Biological processregulation of mitotic cell cycle
GO_0030174Biological processregulation of DNA-templated DNA replication initiation
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0044458Biological processmotile cilium assembly
GO_0005730Cellular componentnucleolus
GO_0016604Cellular componentnuclear body
GO_0005634Cellular componentnucleus
GO_0005515Molecular functionprotein binding
GO_0042802Molecular functionidentical protein binding

IV. Literature review

[source]
Gene nameMCIDAS
Protein nameMulticilin (Multiciliate differentiation and DNA synthesis-associated cell cycle protein) (McIdas protein) (Protein Idas)
Multiciliate differentiation and DNA synthesis associated cell cycle protein
SynonymsMCI
IDAS
MCIN
DescriptionFUNCTION: Transcription regulator specifically required for multiciliate cell differentiation . Acts in a multiprotein complex containing E2F4 and E2F5 that binds and activates genes required for centriole biogenesis. Required for the deuterosome-mediated acentriolar pathway . Plays a role in mitotic cell cycle progression by promoting cell cycle exit. Modulates GMNN activity by reducing its affinity for CDT1 . .

AccessionsENST00000513312.3
D6RGH6
ENST00000513468.5
I6L8E2