Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| adipocyte | 8 studies | 24% ± 10% | |
| epithelial cell | 6 studies | 36% ± 17% | |
| endothelial cell | 4 studies | 21% ± 3% | |
| dendritic cell | 4 studies | 22% ± 2% | |
| cardiac muscle cell | 3 studies | 17% ± 2% | |
| abnormal cell | 3 studies | 21% ± 6% | |
| basal cell | 3 studies | 26% ± 7% | |
| transit amplifying cell | 3 studies | 28% ± 12% | |
| hepatocyte | 3 studies | 37% ± 15% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| liver | 3 studies | 22% ± 6% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| stomach | 100% | 3560.16 | 359 / 359 | 100% | 64.44 | 286 / 286 |
| esophagus | 100% | 2956.76 | 1443 / 1445 | 100% | 52.81 | 183 / 183 |
| intestine | 100% | 3282.82 | 966 / 966 | 100% | 63.75 | 525 / 527 |
| liver | 100% | 7581.55 | 226 / 226 | 100% | 57.48 | 404 / 406 |
| breast | 100% | 5059.30 | 459 / 459 | 99% | 141.12 | 1112 / 1118 |
| prostate | 100% | 5810.17 | 245 / 245 | 99% | 281.07 | 498 / 502 |
| bladder | 100% | 3655.81 | 21 / 21 | 99% | 57.93 | 499 / 504 |
| kidney | 100% | 4975.29 | 89 / 89 | 99% | 48.46 | 891 / 901 |
| ovary | 100% | 2694.62 | 180 / 180 | 99% | 44.79 | 425 / 430 |
| brain | 99% | 2161.93 | 2603 / 2642 | 100% | 41.49 | 703 / 705 |
| thymus | 100% | 5301.40 | 653 / 653 | 98% | 52.33 | 593 / 605 |
| skin | 100% | 3432.08 | 1809 / 1809 | 98% | 41.60 | 462 / 472 |
| lung | 99% | 2462.70 | 570 / 578 | 99% | 43.82 | 1144 / 1155 |
| pancreas | 100% | 2578.81 | 327 / 328 | 97% | 36.40 | 173 / 178 |
| uterus | 100% | 2338.08 | 170 / 170 | 97% | 41.43 | 443 / 459 |
| adrenal gland | 100% | 8344.82 | 258 / 258 | 88% | 38.20 | 202 / 230 |
| adipose | 100% | 3672.79 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| muscle | 100% | 3442.38 | 803 / 803 | 0% | 0 | 0 / 0 |
| spleen | 100% | 2943.26 | 241 / 241 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 100% | 20.92 | 1 / 1 |
| blood vessel | 100% | 2518.13 | 1334 / 1335 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 98% | 47.39 | 44 / 45 |
| lymph node | 0% | 0 | 0 / 0 | 97% | 42.18 | 28 / 29 |
| heart | 96% | 4939.33 | 825 / 861 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 95% | 30.34 | 76 / 80 |
| peripheral blood | 48% | 2410.33 | 449 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0006552 | Biological process | L-leucine catabolic process |
| GO_0009083 | Biological process | branched-chain amino acid catabolic process |
| GO_0015936 | Biological process | coenzyme A metabolic process |
| GO_1905202 | Cellular component | methylcrotonoyl-CoA carboxylase complex |
| GO_0002169 | Cellular component | 3-methylcrotonyl-CoA carboxylase complex, mitochondrial |
| GO_0005829 | Cellular component | cytosol |
| GO_0005759 | Cellular component | mitochondrial matrix |
| GO_0005739 | Cellular component | mitochondrion |
| GO_0004485 | Molecular function | methylcrotonoyl-CoA carboxylase activity |
| GO_0005515 | Molecular function | protein binding |
| GO_0005524 | Molecular function | ATP binding |
| Gene name | MCCC2 |
| Protein name | Methylcrotonyl-CoA carboxylase subunit 2 methylcrotonoyl-CoA carboxylase (EC 6.4.1.4) (3-methylcrotonyl-CoA carboxylase 2) (3-methylcrotonyl-CoA carboxylase non-biotin-containing subunit) (3-methylcrotonyl-CoA:carbon dioxide ligase subunit beta) Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial (MCCase subunit beta) (EC 6.4.1.4) (3-methylcrotonyl-CoA carboxylase 2) (3-methylcrotonyl-CoA carboxylase non-biotin-containing subunit) (3-methylcrotonyl-CoA:carbon dioxide ligase subunit beta) |
| Synonyms | MCCB hCG_37849 |
| Description | FUNCTION: Carboxyltransferase subunit of the 3-methylcrotonyl-CoA carboxylase, an enzyme that catalyzes the conversion of 3-methylcrotonyl-CoA to 3-methylglutaconyl-CoA, a critical step for leucine and isovaleric acid catabolism. . |
| Accessions | Q9HCC0 ENST00000683429.1 ENST00000683098.1 A0A804HJ24 ENST00000509539.3 ENST00000683789.1 [Q9HCC0-2] A0A804HJ84 A0A804HKE8 A0A804HJ31 ENST00000683258.1 A0A0G2JM88 ENST00000684530.1 A0A804HL02 A0A804HK37 ENST00000684254.1 ENST00000340941.11 [Q9HCC0-1] A0A804HJW2 ENST00000684132.1 ENST00000616108.4 A0A0D9SFE9 ENST00000682541.1 A0A804HJL2 ENST00000682687.1 ENST00000684310.1 A0A804HKN6 ENST00000628716.2 ENST00000682045.1 A0A804HJC1 D6RDF7 ENST00000683339.1 ENST00000682727.1 ENST00000626890.1 ENST00000683882.1 ENST00000682876.1 A0A804HKH3 ENST00000683665.1 A0A804HJW5 ENST00000613643.1 A0A804HHS4 A0A804HIH3 A0A804HLJ9 ENST00000509358.7 A0A0S2Z5R4 ENST00000683403.1 D6R9R1 ENST00000512218.6 A0A804HIQ3 ENST00000681968.1 ENST00000684024.1 D6RD67 ENST00000629193.3 ENST00000628261.2 ENST00000682214.1 |
