MC1R | OmnibusX

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
skin	99%	557.63	1790 / 1809	94%	6.16	445 / 472
adrenal gland	98%	487.52	253 / 258	88%	2.85	203 / 230
thymus	100%	2244.91	653 / 653	83%	2.26	501 / 605
bladder	100%	752.71	21 / 21	69%	1.82	348 / 504
esophagus	94%	513.17	1355 / 1445	74%	1.92	136 / 183
uterus	99%	760.46	169 / 170	66%	1.49	302 / 459
pancreas	77%	272.84	254 / 328	88%	2.40	156 / 178
prostate	100%	1138.05	244 / 245	63%	1.31	317 / 502
brain	85%	756.57	2239 / 2642	77%	1.81	543 / 705
lung	99%	589.40	574 / 578	62%	1.48	712 / 1155
kidney	100%	850.03	89 / 89	61%	1.63	549 / 901
breast	94%	535.02	432 / 459	64%	1.34	715 / 1118
ovary	100%	1096.19	180 / 180	53%	1.11	227 / 430
intestine	99%	700.37	956 / 966	52%	1.20	275 / 527
stomach	92%	414.57	332 / 359	44%	0.92	127 / 286
spleen	100%	639.90	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	1.99	1 / 1
adipose	95%	469.31	1145 / 1204	0%	0	0 / 0
blood vessel	89%	429.58	1187 / 1335	0%	0	0 / 0
heart	86%	340.52	744 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	80%	2.52	64 / 80
liver	50%	127.72	113 / 226	18%	0.44	75 / 406
peripheral blood	57%	198.54	528 / 929	0%	0	0 / 0
tonsil	0%	0	0 / 0	36%	0.56	16 / 45
lymph node	0%	0	0 / 0	31%	0.73	9 / 29
muscle	21%	59.15	168 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

IV. Literature review

Gene name	MC1R
Protein name	Melanocortin 1 receptor Melanocyte-stimulating hormone receptor (MSH-R) (Melanocortin receptor 1) (MC1-R) Melanocyte-stimulating hormone receptor (MSH-R) (Melanocortin receptor 1)
Synonyms	hCG_2039647 MSHR
Description	FUNCTION: Receptor for MSH (alpha, beta and gamma) and ACTH . The activity of this receptor is mediated by G proteins which activate adenylate cyclase . Mediates melanogenesis, the production of eumelanin (black/brown) and phaeomelanin (red/yellow), via regulation of cAMP signaling in melanocytes . . FUNCTION: Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. . FUNCTION: Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. . FUNCTION: Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. . FUNCTION: Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. . FUNCTION: Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. . FUNCTION: Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. . FUNCTION: Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. . FUNCTION: Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. . FUNCTION: Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. . FUNCTION: Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. . FUNCTION: Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. . FUNCTION: Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. . FUNCTION: Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. . FUNCTION: Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. . FUNCTION: Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. . FUNCTION: Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. . FUNCTION: Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. . FUNCTION: Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. . FUNCTION: Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. . FUNCTION: Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. . FUNCTION: Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. . FUNCTION: Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. . FUNCTION: Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. . FUNCTION: Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. . FUNCTION: Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. . FUNCTION: Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. . FUNCTION: Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. . FUNCTION: Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. . FUNCTION: Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. . FUNCTION: Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. . FUNCTION: Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. . FUNCTION: Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. . FUNCTION: Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. . FUNCTION: Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. . FUNCTION: Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. . FUNCTION: Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. . FUNCTION: Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. . FUNCTION: Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. . FUNCTION: Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. . FUNCTION: Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. . FUNCTION: Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. . FUNCTION: Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. . FUNCTION: Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. . FUNCTION: Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. . FUNCTION: Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. . FUNCTION: Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. . FUNCTION: Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. . FUNCTION: Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. . FUNCTION: Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. . FUNCTION: Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. . FUNCTION: Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. . FUNCTION: Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. . FUNCTION: Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. . FUNCTION: Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. . FUNCTION: Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. . FUNCTION: Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. . FUNCTION: Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. . FUNCTION: Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. . FUNCTION: Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. . FUNCTION: Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. . FUNCTION: Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. . FUNCTION: Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. .
Accessions	V9Q5S2 V9QCQ4 A0A0P0H2M3 Q6UR96 ENST00000639847.1 A0A0P0HX13 Q1JUM3 V9Q977 V9QDQ6 A0A0P0H5M6 G3V4F0 Q1JUM0 V9QB02 Q1JUM2 A0A0P0HUG3 A0A0P0HNC1 V9Q7F1 Q6UR95 A0A0P0HNE9 V9QAE0 A0A0P0H5W0 V9QAW3 Q1JUL9 A0A0P0HB24 Q6UR92 A0A0P0HJ83 Q01726 V9QBY6 A0A0P0GPT4 A0A0P0H2Q4 ENST00000555427.1 Q6URA0 V9QAR2 ENST00000555147.2 V9QB58 V9Q8N1 A0A0P0HTC9 A0A0P0H5P8 Q6UR97 A0A0P0HAZ5 V9Q9R8 A8WAA1 Q1JUL6 Q1JUM4 Q6UR98 Q1JUL8 A0A0P0H5T8 V9QDN7 Q86YW1 A0A0P0GPS5 A0A0N7IL20 Q6UR99 Q1JUL4 V9QDF4 V9Q8F1 V9QDP7 A0A0N7IL16 Q1JUM5 V9Q671 V9QC66 A0A0P0HX31 V9Q9P5 Q6UR94 A0A0P0HUF4 V9Q783 A0A0P0HT77 V9QC17

GO_0019233	Biological process	sensory perception of pain
GO_2000253	Biological process	positive regulation of feeding behavior
GO_0009650	Biological process	UV protection
GO_0042438	Biological process	melanin biosynthetic process
GO_0070914	Biological process	UV-damage excision repair
GO_0035556	Biological process	intracellular signal transduction
GO_0010739	Biological process	positive regulation of protein kinase A signaling
GO_0043473	Biological process	pigmentation
GO_0007189	Biological process	adenylate cyclase-activating G protein-coupled receptor signaling pathway
GO_0007187	Biological process	G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO_0090037	Biological process	positive regulation of protein kinase C signaling
GO_0032720	Biological process	negative regulation of tumor necrosis factor production
GO_0019222	Biological process	regulation of metabolic process
GO_0045944	Biological process	positive regulation of transcription by RNA polymerase II
GO_0005886	Cellular component	plasma membrane
GO_0005737	Cellular component	cytoplasm
GO_0004977	Molecular function	melanocortin receptor activity
GO_0042562	Molecular function	hormone binding
GO_0031625	Molecular function	ubiquitin protein ligase binding
GO_0008528	Molecular function	G protein-coupled peptide receptor activity
GO_0004980	Molecular function	melanocyte-stimulating hormone receptor activity
GO_0005515	Molecular function	protein binding

MC1R report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review